TY - JOUR
T1 - Potential celiac disease in type 1 diabetes
T2 - A multicenter study
AU - The Study-Group on Diabetes of Italian Society of Pediatric Endocrinology and Diabetology (ISPED)
AU - Franzese, Adriana
AU - Iafusco, Dario
AU - Spadaro, Raffaella
AU - Cavaliere, Olmina
AU - Prisco, Francesco
AU - Auricchio, Renata
AU - Troncone, Riccardo
AU - Valerio, Giuliana
AU - Lera, R.
AU - Fontana, F.
AU - Cherubini, V.
AU - Biagioni, M.
AU - Pasquino, B.
AU - Gallo, F.
AU - Suprani, T.
AU - Tumini, S.
AU - Lazzaro, N.
AU - Toni, S.
AU - D'Annunzio, G.
AU - Emmanuele, V.
AU - Bruzzese, M.
AU - Lombardo, F.
AU - Bonfanti, R.
AU - Tronconi, G. M.
AU - Iughetti, L.
AU - Monciotti, C.
AU - Cardella, F.
AU - Chiari, G.
AU - Vanelli, M.
AU - Calcaterra, V.
AU - Federico, G.
AU - Crino, A.
AU - Cappa, M.
AU - Patera, I.
AU - Negro, I.
AU - Delvecchio, M.
AU - Rabbone, I.
AU - Guerraggio, L.
AU - Salvatoni, A.
AU - Costantini, C.
AU - Pinelli, L.
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Aims: To describe the prevalence of potential celiac disease (pot-CD) in young patients with type 1 diabetes mellitus (T1DM) and characterize their clinical features. Methods: This cross-sectional multicenter study involved 8717 T1DM patients from 31 Italian centers. Information was collected on the total number of T1DM patients, CD patients and pot-CD patients. The following data were collected on pot-CD patients: gender, age at T1DM diagnosis, age at the first CD serological positivity, presence of CD-related symptoms, presence of other autoimmune disorders and treatment with gluten free diet (GFD). One thousand-three-hundred-sixty-one patients who were positive for CD serology were the control group. Results: CD serological positivity was found in 7.2% T1DM patients. Prevalence of pot-CD was 12.2% (n = 77) among CD positive patients: symptoms were present in 12/77; a third autoimmune disorder was found in 15 patients. Prevalence of pot-CD in the control population was 8.4% (n = 114; p = 0.005). No difference was found with regard to clinical features. Only few symptomatic patients were on GFD both in T1DM and control patients. Conclusions: A higher prevalence of pot-CD was found in T1DM patients, that may be ascribed to the routine screening, although the influence of genetic factors cannot be excluded.
AB - Aims: To describe the prevalence of potential celiac disease (pot-CD) in young patients with type 1 diabetes mellitus (T1DM) and characterize their clinical features. Methods: This cross-sectional multicenter study involved 8717 T1DM patients from 31 Italian centers. Information was collected on the total number of T1DM patients, CD patients and pot-CD patients. The following data were collected on pot-CD patients: gender, age at T1DM diagnosis, age at the first CD serological positivity, presence of CD-related symptoms, presence of other autoimmune disorders and treatment with gluten free diet (GFD). One thousand-three-hundred-sixty-one patients who were positive for CD serology were the control group. Results: CD serological positivity was found in 7.2% T1DM patients. Prevalence of pot-CD was 12.2% (n = 77) among CD positive patients: symptoms were present in 12/77; a third autoimmune disorder was found in 15 patients. Prevalence of pot-CD in the control population was 8.4% (n = 114; p = 0.005). No difference was found with regard to clinical features. Only few symptomatic patients were on GFD both in T1DM and control patients. Conclusions: A higher prevalence of pot-CD was found in T1DM patients, that may be ascribed to the routine screening, although the influence of genetic factors cannot be excluded.
KW - Autoimmune disorders
KW - Celiac disease
KW - Potential celiac disease
KW - Type 1 diabetes
UR - https://www.scopus.com/pages/publications/79954568841
U2 - 10.1016/j.diabres.2010.12.028
DO - 10.1016/j.diabres.2010.12.028
M3 - Article
SN - 0168-8227
VL - 92
SP - 53
EP - 56
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 1
ER -
