Possible role of prolactin in the modification of medial basal hypothalamic glutamic acid decarboxylase activity

Agata Prato; Giuseppe Clementi; Ferdinanco Nicoletti; Pier Luigi Canonico; Francesco Patti; Daniele Filippo Condorelli; Rosa Maria Di Giorgio; Filippo Drago

doi:10.1016/0014-2999(81)90404-0

Possible role of prolactin in the modification of medial basal hypothalamic glutamic acid decarboxylase activity

Agata Prato
, Giuseppe Clementi
, Ferdinanco Nicoletti
, Pier Luigi Canonico
, Francesco Patti
, Daniele Filippo Condorelli
, Rosa Maria Di Giorgio
, Filippo Drago

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of acute and chronic injections of haloperidol, sulpiride and apomorphine on serum prolactin (PRL) levels and medial basal hypothalamus (MBH) glutamic acid decarboxylase (GAD) activity were investigated in male rats. Parallel changes in PRL and GAD activity were observed in acutely treated animals. Conversely, a return to normal of the GAD activity associated with high plasma PRL levels was induced by chronic haloperidol and sulpiride treatment. Results are discussed in the light of the possible existence of a hypothetical PRL-γ-aminobutyric acid (GABA) subsidiary feedback loop.

Original language	English
Pages (from-to)	169-172
Number of pages	4
Journal	European Journal of Pharmacology
Volume	71
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(81)90404-0
Publication status	Published - 24 Apr 1981
Externally published	Yes

Keywords

GABA
Glutamic acid decarboxylase
Medial basal hypothalamus
Prolactin

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10.1016/0014-2999(81)90404-0

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title = "Possible role of prolactin in the modification of medial basal hypothalamic glutamic acid decarboxylase activity",

abstract = "The effects of acute and chronic injections of haloperidol, sulpiride and apomorphine on serum prolactin (PRL) levels and medial basal hypothalamus (MBH) glutamic acid decarboxylase (GAD) activity were investigated in male rats. Parallel changes in PRL and GAD activity were observed in acutely treated animals. Conversely, a return to normal of the GAD activity associated with high plasma PRL levels was induced by chronic haloperidol and sulpiride treatment. Results are discussed in the light of the possible existence of a hypothetical PRL-γ-aminobutyric acid (GABA) subsidiary feedback loop.",

keywords = "GABA, Glutamic acid decarboxylase, Medial basal hypothalamus, Prolactin",

author = "Agata Prato and Giuseppe Clementi and Ferdinanco Nicoletti and Canonico, \{Pier Luigi\} and Francesco Patti and Condorelli, \{Daniele Filippo\} and \{Di Giorgio\}, \{Rosa Maria\} and Filippo Drago",

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doi = "10.1016/0014-2999(81)90404-0",

language = "English",

volume = "71",

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TY - JOUR

T1 - Possible role of prolactin in the modification of medial basal hypothalamic glutamic acid decarboxylase activity

AU - Prato, Agata

AU - Clementi, Giuseppe

AU - Nicoletti, Ferdinanco

AU - Canonico, Pier Luigi

AU - Patti, Francesco

AU - Condorelli, Daniele Filippo

AU - Di Giorgio, Rosa Maria

AU - Drago, Filippo

PY - 1981/4/24

Y1 - 1981/4/24

N2 - The effects of acute and chronic injections of haloperidol, sulpiride and apomorphine on serum prolactin (PRL) levels and medial basal hypothalamus (MBH) glutamic acid decarboxylase (GAD) activity were investigated in male rats. Parallel changes in PRL and GAD activity were observed in acutely treated animals. Conversely, a return to normal of the GAD activity associated with high plasma PRL levels was induced by chronic haloperidol and sulpiride treatment. Results are discussed in the light of the possible existence of a hypothetical PRL-γ-aminobutyric acid (GABA) subsidiary feedback loop.

AB - The effects of acute and chronic injections of haloperidol, sulpiride and apomorphine on serum prolactin (PRL) levels and medial basal hypothalamus (MBH) glutamic acid decarboxylase (GAD) activity were investigated in male rats. Parallel changes in PRL and GAD activity were observed in acutely treated animals. Conversely, a return to normal of the GAD activity associated with high plasma PRL levels was induced by chronic haloperidol and sulpiride treatment. Results are discussed in the light of the possible existence of a hypothetical PRL-γ-aminobutyric acid (GABA) subsidiary feedback loop.

KW - GABA

KW - Glutamic acid decarboxylase

KW - Medial basal hypothalamus

KW - Prolactin

UR - https://www.scopus.com/pages/publications/0019464966

U2 - 10.1016/0014-2999(81)90404-0

DO - 10.1016/0014-2999(81)90404-0

M3 - Article

SN - 0014-2999

VL - 71

SP - 169

EP - 172

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Possible role of prolactin in the modification of medial basal hypothalamic glutamic acid decarboxylase activity

Abstract

Keywords

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