Polyurethane-based biomaterials for shape-adjustable cardiovascular devices

A. Silvestri; P. M. Serafini; S. Sartori; P. Ferrando; F. Boccafoschi; S. Milione; L. Conzatti; G. Ciardelli

doi:10.1002/app.34779

Polyurethane-based biomaterials for shape-adjustable cardiovascular devices

A. Silvestri
, P. M. Serafini
, S. Sartori
, P. Ferrando
, F. Boccafoschi
, S. Milione
, L. Conzatti
, G. Ciardelli

Department of Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A series of biostable polyurethane (PUR) formulations, including a composite containing a clay as filler, were prepared as new biomaterials for cardiovascular applications. Poly(dimethyl siloxane) and poly(tetramethylene oxide) were selected as macrodiols because of their mechanical properties and the high hydrolysis resistance they confer to PURs. 1,6-Diisocyanatohexane and 1,4-cyclohexane dimethanol were used as a diisocyanate and chain extender, respectively. The polymeric products were chemically, thermally, and mechanically characterized. Thermomechanical characterizations highlighted that some of the obtained formulations are promising materials for applications in the cardiovascular field, in particular, for the realization of annuloplastic rings in mitral valve repair.

Original language	English
Pages (from-to)	3661-3671
Number of pages	11
Journal	Journal of Applied Polymer Science
Volume	122
Issue number	6
DOIs	https://doi.org/10.1002/app.34779
Publication status	Published - 15 Dec 2011

Keywords

biomaterials
mechanical properties
polyurethanes

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10.1002/app.34779

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abstract = "A series of biostable polyurethane (PUR) formulations, including a composite containing a clay as filler, were prepared as new biomaterials for cardiovascular applications. Poly(dimethyl siloxane) and poly(tetramethylene oxide) were selected as macrodiols because of their mechanical properties and the high hydrolysis resistance they confer to PURs. 1,6-Diisocyanatohexane and 1,4-cyclohexane dimethanol were used as a diisocyanate and chain extender, respectively. The polymeric products were chemically, thermally, and mechanically characterized. Thermomechanical characterizations highlighted that some of the obtained formulations are promising materials for applications in the cardiovascular field, in particular, for the realization of annuloplastic rings in mitral valve repair.",

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AU - Silvestri, A.

AU - Serafini, P. M.

AU - Sartori, S.

AU - Ferrando, P.

AU - Boccafoschi, F.

AU - Milione, S.

AU - Conzatti, L.

AU - Ciardelli, G.

PY - 2011/12/15

Y1 - 2011/12/15

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AB - A series of biostable polyurethane (PUR) formulations, including a composite containing a clay as filler, were prepared as new biomaterials for cardiovascular applications. Poly(dimethyl siloxane) and poly(tetramethylene oxide) were selected as macrodiols because of their mechanical properties and the high hydrolysis resistance they confer to PURs. 1,6-Diisocyanatohexane and 1,4-cyclohexane dimethanol were used as a diisocyanate and chain extender, respectively. The polymeric products were chemically, thermally, and mechanically characterized. Thermomechanical characterizations highlighted that some of the obtained formulations are promising materials for applications in the cardiovascular field, in particular, for the realization of annuloplastic rings in mitral valve repair.

KW - biomaterials

KW - mechanical properties

KW - polyurethanes

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SP - 3661

EP - 3671

JO - Journal of Applied Polymer Science

JF - Journal of Applied Polymer Science

IS - 6

ER -

Polyurethane-based biomaterials for shape-adjustable cardiovascular devices

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Keywords

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