Poly(ethylene glycol) imidazolyl formates as oligomeric drug-binding matrices

L. Tondelli; Michele LAUS; A. S. Angeloni; P. Ferruti

Poly(ethylene glycol) imidazolyl formates as oligomeric drug-binding matrices

L. Tondelli
, Michele LAUS
, A. S. Angeloni
, P. Ferruti

Department of Science and Technological Innovation

Research output: Contribution to journal › Article › peer-review

Abstract

Poly(ethylene glycol)s of molecular weight 200 and 1000 have been functionalized by reaction with N,N-carbonyldiimidazole. The resulting imidazolyl formates could be isolated in a pure state and proved to be able to react with model amines and hydroxylated compounds giving the corresponding urethanes or carbonates. These results indicate that the new activated matrices can be used for the preparation of oligomeric derivatives of aminated or hydroxylated drugs.

Original language	English
Pages (from-to)	251-257
Number of pages	7
Journal	Journal of Controlled Release
Volume	1
Publication status	Published - 1985

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title = "Poly(ethylene glycol) imidazolyl formates as oligomeric drug-binding matrices",

abstract = "Poly(ethylene glycol)s of molecular weight 200 and 1000 have been functionalized by reaction with N,N-carbonyldiimidazole. The resulting imidazolyl formates could be isolated in a pure state and proved to be able to react with model amines and hydroxylated compounds giving the corresponding urethanes or carbonates. These results indicate that the new activated matrices can be used for the preparation of oligomeric derivatives of aminated or hydroxylated drugs.",

author = "L. Tondelli and Michele LAUS and Angeloni, \{A. S.\} and P. Ferruti",

note = "Funding Information: This work has been supported by the “Progetto Finalizzato Chimica Fine e Secon-daria”{\textquoteright} (grant No. 8300219.95) of the Italian National Council of Researches (CNR).",

year = "1985",

language = "English",

volume = "1",

pages = "251--257",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Poly(ethylene glycol) imidazolyl formates as oligomeric drug-binding matrices

AU - Tondelli, L.

AU - LAUS, Michele

AU - Angeloni, A. S.

AU - Ferruti, P.

N1 - Funding Information: This work has been supported by the “Progetto Finalizzato Chimica Fine e Secon-daria”’ (grant No. 8300219.95) of the Italian National Council of Researches (CNR).

PY - 1985

Y1 - 1985

N2 - Poly(ethylene glycol)s of molecular weight 200 and 1000 have been functionalized by reaction with N,N-carbonyldiimidazole. The resulting imidazolyl formates could be isolated in a pure state and proved to be able to react with model amines and hydroxylated compounds giving the corresponding urethanes or carbonates. These results indicate that the new activated matrices can be used for the preparation of oligomeric derivatives of aminated or hydroxylated drugs.

AB - Poly(ethylene glycol)s of molecular weight 200 and 1000 have been functionalized by reaction with N,N-carbonyldiimidazole. The resulting imidazolyl formates could be isolated in a pure state and proved to be able to react with model amines and hydroxylated compounds giving the corresponding urethanes or carbonates. These results indicate that the new activated matrices can be used for the preparation of oligomeric derivatives of aminated or hydroxylated drugs.

UR - https://iris.uniupo.it/handle/11579/2310

M3 - Article

SN - 0168-3659

VL - 1

SP - 251

EP - 257

JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Poly(ethylene glycol) imidazolyl formates as oligomeric drug-binding matrices

Abstract

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