Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line

Antonio Caldarelli; Valeria De Biasio; Giovanni B. Giovenzana; Gianpiero Mastronardo; Roberto Negri

doi:10.1007/s11030-014-9519-5

Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line

Antonio Caldarelli
, Valeria De Biasio
, Giovanni B. Giovenzana
, Gianpiero Mastronardo
, Roberto Negri

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Cytotoxicity in the μM range was observed in cancer cell lines treated with N,N,N' ,N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.

Original language	English
Pages (from-to)	879-886
Number of pages	8
Journal	Molecular Diversity
Volume	18
Issue number	4
DOIs	https://doi.org/10.1007/s11030-014-9519-5
Publication status	Published - 9 Oct 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cytotoxicity
G1 phase arrest
SAR
Tetrabenzyldiaminocyclopentenone

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10.1007/s11030-014-9519-5

Cite this

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title = "Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line",

abstract = "Cytotoxicity in the μM range was observed in cancer cell lines treated with N,N,N' ,N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.",

keywords = "Cytotoxicity, G1 phase arrest, SAR, Tetrabenzyldiaminocyclopentenone",

author = "Antonio Caldarelli and \{De Biasio\}, Valeria and Giovenzana, \{Giovanni B.\} and Gianpiero Mastronardo and Roberto Negri",

note = "Publisher Copyright: {\textcopyright} 2014, Springer International Publishing Switzerland.",

year = "2014",

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day = "9",

doi = "10.1007/s11030-014-9519-5",

language = "English",

volume = "18",

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journal = "Molecular Diversity",

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TY - JOUR

T1 - Polybenzylated alicyclic 1,2-diamines

T2 - cytotoxicity and G1 phase arrest in cancer cell line

AU - Caldarelli, Antonio

AU - De Biasio, Valeria

AU - Giovenzana, Giovanni B.

AU - Mastronardo, Gianpiero

AU - Negri, Roberto

PY - 2014/10/9

Y1 - 2014/10/9

N2 - Cytotoxicity in the μM range was observed in cancer cell lines treated with N,N,N' ,N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.

AB - Cytotoxicity in the μM range was observed in cancer cell lines treated with N,N,N' ,N'-tetrabenzyl-4,5-diamino-2-cyclopentenone. Cell cycle analysis on HeLa cells showed a clear G1 phase arrest. A preliminary SAR on structural analogs was performed in order to identify the pharmacophores.

KW - Cytotoxicity

KW - G1 phase arrest

KW - SAR

KW - Tetrabenzyldiaminocyclopentenone

UR - https://www.scopus.com/pages/publications/84910016871

U2 - 10.1007/s11030-014-9519-5

DO - 10.1007/s11030-014-9519-5

M3 - Article

SN - 1381-1991

VL - 18

SP - 879

EP - 886

JO - Molecular Diversity

JF - Molecular Diversity

IS - 4

ER -

Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line

Abstract

UN SDGs

Keywords

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