Plasma rich in growth factors (PRGF) for the promotion of bone cell proliferation and tissue regeneration

Matteo Brucoli, Roberta Sonzini, Michela Bosetti, Paolo Boffano, Arnaldo Benech

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Over the past few years, studies about growth factors have been increasingly developed and the knowledge of their role in stimulating cell proliferation and differentiation used for therapeutic purposes. This study aims to compare a platelets concentrate, the plasma rich in growth factors (PRGF) to a control, consisting of cellulose membranes, to evaluate in vitro the cellular adhesion and migration of human osteoblasts (hOb) and understand if the use of platelets concentrates could be an advantage in view of bone tissue regeneration. Study design: Twenty-seven human donors provided 27 blood samples used to make 54 samples: 27 for PRGF and 27 for the control group. PRGFs and controls were incubated for 48 h in sterility in 1 ml of culture with 105 hOb and hOb in the scaffolds were then quantified. Results: In PRGF samples, hObs were more numerous than in controls. (T = 6.6964, p < 0.0001). Conclusions: Human osteoblasts are driven to colonize PRGFs with a greater efficacy than negative controls, probably due to the presence of chemokines and growth factors in PRGFs.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalOral and Maxillofacial Surgery
Volume22
Issue number3
DOIs
Publication statusPublished - 1 Sept 2018

Keywords

  • Bone remodeling/regeneration
  • Growth factors
  • Osteoblasts
  • PRGF
  • Regenerative medicine

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