Plasma central nervous system biomarkers in heavily treatment-experienced people with HIV in the PRESTIGIO registry

Andrea CALCAGNO; Martina Strano; Riccardo Lolatto; Riccardo Vercesi; Alessandra Mandelli; Miriam Antonucci; Vincenzo Spagnuolo; Tommaso Clemente; Daniela Francisci; Giovanni Cenderello; Ornella Schioppa; Laura Comi; Roberto Furlan; Antonella Castagna; Paola Cinque

doi:10.1097/QAD.0000000000004483

Plasma central nervous system biomarkers in heavily treatment-experienced people with HIV in the PRESTIGIO registry

Andrea CALCAGNO
, Martina Strano
, Riccardo Lolatto
, Riccardo Vercesi
, Alessandra Mandelli
, Miriam Antonucci
, Vincenzo Spagnuolo
, Tommaso Clemente
, Daniela Francisci
, Giovanni Cenderello
, Ornella Schioppa
, Laura Comi
, Roberto Furlan
, Antonella Castagna
, Paola Cinque

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the levels of plasma biomarkers of central nervous system (CNS) injury in people with HIV and four-class drug resistance (heavily treatment-experienced, HTE), and in virally suppressed, non-HTE controls. Biomarkers included NFL, t-Tau, GFAP, and UCH-L1. No evidence was found for higher biomarker levels in HTE individuals. Age, comorbidities, and CD4+ cell count were stronger predictors of higher biomarker levels than HTE status or viral replication. Effective management may mitigate CNS injury despite long-term HIV infection and treatment resistance.

Original language	English
Pages (from-to)	1045-1049
Number of pages	5
Journal	AIDS
Volume	40
Issue number	7
DOIs	https://doi.org/10.1097/QAD.0000000000004483
Publication status	Published - 2026

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SDG 3 Good Health and Well-being

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10.1097/QAD.0000000000004483

https://hdl.handle.net/11579/237523

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CALCAGNO, A., Strano, M., Lolatto, R., Vercesi, R., Mandelli, A., Antonucci, M., Spagnuolo, V., Clemente, T., Francisci, D., Cenderello, G., Schioppa, O., Comi, L., Furlan, R., Castagna, A., & Cinque, P. (2026). Plasma central nervous system biomarkers in heavily treatment-experienced people with HIV in the PRESTIGIO registry. AIDS, 40(7), 1045-1049. https://doi.org/10.1097/QAD.0000000000004483

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title = "Plasma central nervous system biomarkers in heavily treatment-experienced people with HIV in the PRESTIGIO registry",

abstract = "We evaluated the levels of plasma biomarkers of central nervous system (CNS) injury in people with HIV and four-class drug resistance (heavily treatment-experienced, HTE), and in virally suppressed, non-HTE controls. Biomarkers included NFL, t-Tau, GFAP, and UCH-L1. No evidence was found for higher biomarker levels in HTE individuals. Age, comorbidities, and CD4+ cell count were stronger predictors of higher biomarker levels than HTE status or viral replication. Effective management may mitigate CNS injury despite long-term HIV infection and treatment resistance.",

author = "Andrea CALCAGNO and Martina Strano and Riccardo Lolatto and Riccardo Vercesi and Alessandra Mandelli and Miriam Antonucci and Vincenzo Spagnuolo and Tommaso Clemente and Daniela Francisci and Giovanni Cenderello and Ornella Schioppa and Laura Comi and Roberto Furlan and Antonella Castagna and Paola Cinque",

year = "2026",

doi = "10.1097/QAD.0000000000004483",

language = "English",

volume = "40",

pages = "1045--1049",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

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}

CALCAGNO, A, Strano, M, Lolatto, R, Vercesi, R, Mandelli, A, Antonucci, M, Spagnuolo, V, Clemente, T, Francisci, D, Cenderello, G, Schioppa, O, Comi, L, Furlan, R, Castagna, A & Cinque, P 2026, 'Plasma central nervous system biomarkers in heavily treatment-experienced people with HIV in the PRESTIGIO registry', AIDS, vol. 40, no. 7, pp. 1045-1049. https://doi.org/10.1097/QAD.0000000000004483

TY - JOUR

T1 - Plasma central nervous system biomarkers in heavily treatment-experienced people with HIV in the PRESTIGIO registry

AU - CALCAGNO, Andrea

AU - Strano, Martina

AU - Lolatto, Riccardo

AU - Vercesi, Riccardo

AU - Mandelli, Alessandra

AU - Antonucci, Miriam

AU - Spagnuolo, Vincenzo

AU - Clemente, Tommaso

AU - Francisci, Daniela

AU - Cenderello, Giovanni

AU - Schioppa, Ornella

AU - Comi, Laura

AU - Furlan, Roberto

AU - Castagna, Antonella

AU - Cinque, Paola

PY - 2026

Y1 - 2026

N2 - We evaluated the levels of plasma biomarkers of central nervous system (CNS) injury in people with HIV and four-class drug resistance (heavily treatment-experienced, HTE), and in virally suppressed, non-HTE controls. Biomarkers included NFL, t-Tau, GFAP, and UCH-L1. No evidence was found for higher biomarker levels in HTE individuals. Age, comorbidities, and CD4+ cell count were stronger predictors of higher biomarker levels than HTE status or viral replication. Effective management may mitigate CNS injury despite long-term HIV infection and treatment resistance.

AB - We evaluated the levels of plasma biomarkers of central nervous system (CNS) injury in people with HIV and four-class drug resistance (heavily treatment-experienced, HTE), and in virally suppressed, non-HTE controls. Biomarkers included NFL, t-Tau, GFAP, and UCH-L1. No evidence was found for higher biomarker levels in HTE individuals. Age, comorbidities, and CD4+ cell count were stronger predictors of higher biomarker levels than HTE status or viral replication. Effective management may mitigate CNS injury despite long-term HIV infection and treatment resistance.

UR - https://iris.uniupo.it/handle/11579/237523

U2 - 10.1097/QAD.0000000000004483

DO - 10.1097/QAD.0000000000004483

M3 - Article

SN - 0269-9370

VL - 40

SP - 1045

EP - 1049

JO - AIDS

JF - AIDS

IS - 7

ER -

Plasma central nervous system biomarkers in heavily treatment-experienced people with HIV in the PRESTIGIO registry

Abstract

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