Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles

Giuseppe Ferrauto; Fabio Carniato; Enza Di Gregorio; Mauro Botta; Lorenzo Tei

doi:10.1039/c9nr06524e

Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles

Giuseppe Ferrauto
, Fabio Carniato
, Enza Di Gregorio
, Mauro Botta
, Lorenzo Tei

Department of Science and Technological Innovation

Research output: Contribution to journal › Article › peer-review

Abstract

A theranostic nanosystem based on indocyanine green (ICG) covalently conjugated to mesoporous silica nanoparticles (MSNs) loaded with the anticancer drug mitoxantrone (MTX) is proposed as an innovative photoacoustic probe. Taking advantage of the characteristic PA signal displayed by both ICG and MTX, a PA-ratiometric approach was applied to assess the drug release profile from the MSNs. After complete in vitro characterization of the nanoprobe, a proof-of-concept study has been carried out in tumour-bearing mice to evaluate in vivo its effectiveness for cancer imaging and chemotherapeutic agent delivery.

Original language	English
Pages (from-to)	18031-18036
Number of pages	6
Journal	Nanoscale
Volume	11
Issue number	39
DOIs	https://doi.org/10.1039/c9nr06524e
Publication status	Published - 21 Oct 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1039/c9nr06524e

Cite this

@article{98b27b46111b4b8d969b4a072b74116b,

title = "Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles",

abstract = "A theranostic nanosystem based on indocyanine green (ICG) covalently conjugated to mesoporous silica nanoparticles (MSNs) loaded with the anticancer drug mitoxantrone (MTX) is proposed as an innovative photoacoustic probe. Taking advantage of the characteristic PA signal displayed by both ICG and MTX, a PA-ratiometric approach was applied to assess the drug release profile from the MSNs. After complete in vitro characterization of the nanoprobe, a proof-of-concept study has been carried out in tumour-bearing mice to evaluate in vivo its effectiveness for cancer imaging and chemotherapeutic agent delivery.",

author = "Giuseppe Ferrauto and Fabio Carniato and \{Di Gregorio\}, Enza and Mauro Botta and Lorenzo Tei",

note = "Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

month = oct,

day = "21",

doi = "10.1039/c9nr06524e",

language = "English",

volume = "11",

pages = "18031--18036",

journal = "Nanoscale",

issn = "2040-3364",

publisher = "Royal Society of Chemistry",

number = "39",

}

TY - JOUR

T1 - Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles

AU - Ferrauto, Giuseppe

AU - Carniato, Fabio

AU - Di Gregorio, Enza

AU - Botta, Mauro

AU - Tei, Lorenzo

PY - 2019/10/21

Y1 - 2019/10/21

N2 - A theranostic nanosystem based on indocyanine green (ICG) covalently conjugated to mesoporous silica nanoparticles (MSNs) loaded with the anticancer drug mitoxantrone (MTX) is proposed as an innovative photoacoustic probe. Taking advantage of the characteristic PA signal displayed by both ICG and MTX, a PA-ratiometric approach was applied to assess the drug release profile from the MSNs. After complete in vitro characterization of the nanoprobe, a proof-of-concept study has been carried out in tumour-bearing mice to evaluate in vivo its effectiveness for cancer imaging and chemotherapeutic agent delivery.

AB - A theranostic nanosystem based on indocyanine green (ICG) covalently conjugated to mesoporous silica nanoparticles (MSNs) loaded with the anticancer drug mitoxantrone (MTX) is proposed as an innovative photoacoustic probe. Taking advantage of the characteristic PA signal displayed by both ICG and MTX, a PA-ratiometric approach was applied to assess the drug release profile from the MSNs. After complete in vitro characterization of the nanoprobe, a proof-of-concept study has been carried out in tumour-bearing mice to evaluate in vivo its effectiveness for cancer imaging and chemotherapeutic agent delivery.

UR - https://www.scopus.com/pages/publications/85073124583

U2 - 10.1039/c9nr06524e

DO - 10.1039/c9nr06524e

M3 - Article

SN - 2040-3364

VL - 11

SP - 18031

EP - 18036

JO - Nanoscale

JF - Nanoscale

IS - 39

ER -

Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this