Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22

Antonio P. Palumbo; Mario Boccadoro; Silvano Battaglio; Paolo Corradini; Bruna Giovinazzo; Giancarlo Avanzi; Giuseppe Ponzio

doi:10.1016/0165-4608(89)90232-X

Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22

Antonio P. Palumbo, Mario Boccadoro, Silvano Battaglio, Paolo Corradini, Bruna Giovinazzo, Giancarlo Avanzi, Giuseppe Ponzio

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).

Original language	English
Pages (from-to)	77-80
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(89)90232-X
Publication status	Published - May 1989
Externally published	Yes

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title = "Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22",

abstract = "We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).",

author = "Palumbo, {Antonio P.} and Mario Boccadoro and Silvano Battaglio and Paolo Corradini and Bruna Giovinazzo and Giancarlo Avanzi and Giuseppe Ponzio",

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T1 - Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22

AU - Palumbo, Antonio P.

AU - Boccadoro, Mario

AU - Battaglio, Silvano

AU - Corradini, Paolo

AU - Giovinazzo, Bruna

AU - Avanzi, Giancarlo

AU - Ponzio, Giuseppe

PY - 1989/5

Y1 - 1989/5

N2 - We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).

AB - We report a case of Philadelphia chromosome (Ph) positive thrombocythemia with a complex translocation. G-banding analysis showed the predominant karyotype to be 46,XX,t(9;15;22). Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia. These data suggest the presence of a complex Ph translocation involving t(9;15;22)(q34.1 or q34.3;q26.1;q11 or q13).

UR - http://www.scopus.com/inward/record.url?scp=0024348832&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(89)90232-X

DO - 10.1016/0165-4608(89)90232-X

M3 - Article

SN - 0165-4608

VL - 39

SP - 77

EP - 80

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

Philadelphia-positive thrombocythemia with a complex translocation involving chromosomes 9, 15, and 22

Abstract

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