Pharmacokinetic Changes during Pregnancy According to Genetic Variants: A Prospective Study in HIV-infected Patients Receiving Atazanavir/Ritonavir

Emanuele Focà; Andrea CALCAGNO; Andrea Bonito; Jessica Cusato; Elisabetta Domenighini; Antonio D'Avolio; Eugenia Quiros Roldan; Laura Trentini; Filippo Castelnuovo; Giovanni Di Perri; Francesco Castelli; Stefano Bonora

doi:10.1128/AAC.00309-18

Pharmacokinetic Changes during Pregnancy According to Genetic Variants: A Prospective Study in HIV-infected Patients Receiving Atazanavir/Ritonavir

Emanuele Focà
, Andrea CALCAGNO
, Andrea Bonito
, Jessica Cusato
, Elisabetta Domenighini
, Antonio D'Avolio
, Eugenia Quiros Roldan
, Laura Trentini
, Filippo Castelnuovo
, Giovanni Di Perri
, Francesco Castelli
, Stefano Bonora

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Atazanavir/ritonavir concentrations change over pregnancy in HIV-positive patients; the impact of genetic variants is unknown. 20 patients were enrolled: antiretrovirals' plasma and intracellular concentrations were measured in addition to single nucleotide polymorphisms in transport affecting genes. Linear logistic regression showed that genetic variants in organic-anion-transporter-1B1 and pregnane-X-receptor encoding genes affected third trimester atazanavir exposure. In this prospective study genetic variants partially explained the observed inter-patient variability in third-trimester antiretrovirals' exposure.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	1
Issue number	1
DOIs	https://doi.org/10.1128/AAC.00309-18
Publication status	Published - 2018

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SDG 3 Good Health and Well-being

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10.1128/AAC.00309-18

https://hdl.handle.net/11579/217001

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Focà, E., CALCAGNO, A., Bonito, A., Cusato, J., Domenighini, E., D'Avolio, A., Roldan, E. Q., Trentini, L., Castelnuovo, F., Perri, G. D., Castelli, F., & Bonora, S. (2018). Pharmacokinetic Changes during Pregnancy According to Genetic Variants: A Prospective Study in HIV-infected Patients Receiving Atazanavir/Ritonavir. Antimicrobial Agents and Chemotherapy, 1(1), 1-5. https://doi.org/10.1128/AAC.00309-18

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title = "Pharmacokinetic Changes during Pregnancy According to Genetic Variants: A Prospective Study in HIV-infected Patients Receiving Atazanavir/Ritonavir",

abstract = "Atazanavir/ritonavir concentrations change over pregnancy in HIV-positive patients; the impact of genetic variants is unknown. 20 patients were enrolled: antiretrovirals' plasma and intracellular concentrations were measured in addition to single nucleotide polymorphisms in transport affecting genes. Linear logistic regression showed that genetic variants in organic-anion-transporter-1B1 and pregnane-X-receptor encoding genes affected third trimester atazanavir exposure. In this prospective study genetic variants partially explained the observed inter-patient variability in third-trimester antiretrovirals' exposure.",

author = "Emanuele Foc{\`a} and Andrea CALCAGNO and Andrea Bonito and Jessica Cusato and Elisabetta Domenighini and Antonio D'Avolio and Roldan, \{Eugenia Quiros\} and Laura Trentini and Filippo Castelnuovo and Perri, \{Giovanni Di\} and Francesco Castelli and Stefano Bonora",

year = "2018",

doi = "10.1128/AAC.00309-18",

language = "English",

volume = "1",

pages = "1--5",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "1",

}

Focà, E, CALCAGNO, A, Bonito, A, Cusato, J, Domenighini, E, D'Avolio, A, Roldan, EQ, Trentini, L, Castelnuovo, F, Perri, GD, Castelli, F & Bonora, S 2018, 'Pharmacokinetic Changes during Pregnancy According to Genetic Variants: A Prospective Study in HIV-infected Patients Receiving Atazanavir/Ritonavir', Antimicrobial Agents and Chemotherapy, vol. 1, no. 1, pp. 1-5. https://doi.org/10.1128/AAC.00309-18

TY - JOUR

T1 - Pharmacokinetic Changes during Pregnancy According to Genetic Variants: A Prospective Study in HIV-infected Patients Receiving Atazanavir/Ritonavir

AU - Focà, Emanuele

AU - CALCAGNO, Andrea

AU - Bonito, Andrea

AU - Cusato, Jessica

AU - Domenighini, Elisabetta

AU - D'Avolio, Antonio

AU - Roldan, Eugenia Quiros

AU - Trentini, Laura

AU - Castelnuovo, Filippo

AU - Perri, Giovanni Di

AU - Castelli, Francesco

AU - Bonora, Stefano

PY - 2018

Y1 - 2018

N2 - Atazanavir/ritonavir concentrations change over pregnancy in HIV-positive patients; the impact of genetic variants is unknown. 20 patients were enrolled: antiretrovirals' plasma and intracellular concentrations were measured in addition to single nucleotide polymorphisms in transport affecting genes. Linear logistic regression showed that genetic variants in organic-anion-transporter-1B1 and pregnane-X-receptor encoding genes affected third trimester atazanavir exposure. In this prospective study genetic variants partially explained the observed inter-patient variability in third-trimester antiretrovirals' exposure.

AB - Atazanavir/ritonavir concentrations change over pregnancy in HIV-positive patients; the impact of genetic variants is unknown. 20 patients were enrolled: antiretrovirals' plasma and intracellular concentrations were measured in addition to single nucleotide polymorphisms in transport affecting genes. Linear logistic regression showed that genetic variants in organic-anion-transporter-1B1 and pregnane-X-receptor encoding genes affected third trimester atazanavir exposure. In this prospective study genetic variants partially explained the observed inter-patient variability in third-trimester antiretrovirals' exposure.

UR - https://iris.uniupo.it/handle/11579/217001

U2 - 10.1128/AAC.00309-18

DO - 10.1128/AAC.00309-18

M3 - Article

SN - 0066-4804

VL - 1

SP - 1

EP - 5

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 1

ER -

Pharmacokinetic Changes during Pregnancy According to Genetic Variants: A Prospective Study in HIV-infected Patients Receiving Atazanavir/Ritonavir

Abstract

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