Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia

Jessica Cusato; Lucio Boglione; Amedeo De Nicolò; Chiara Simona Cardellino; Chiara Carcieri; Giuseppe Cariti; Giovanni Di Perri; Antonio D'Avolio

doi:10.2217/pgs-2016-0040

Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia

Jessica Cusato, Lucio Boglione, Amedeo De Nicolò, Chiara Simona Cardellino, Chiara Carcieri, Giuseppe Cariti, Giovanni Di Perri, Antonio D'Avolio

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: Mixed cryoglobulinemia (MC) is an extra hepatic hepatitis C virus related problem and different studies suggested genetics' role in predicting this complication. We evaluated the influence of SNPs in IL-28B, SLC29A1, SLC28A2, NT5C2, HNF4 and ABCB1 genes in MC prediction. Patients & methods: SNPs were evaluated through real-time PCR. Results: ABCB1 (gene encoding P-glycoprotein) 3435C>T SNP was associated with MC presence (p = 0.034): related to T allele carriers (CC vs CT/TT), we reached a p-value of 0.013. In the logistic regression analysis baseline viral load >600.000 IU/ml (p < 001), IL28B rs8099917/rs12979860 TT/CC (p < 0.001), NT5 (gene encoding for 5' nucleotidase) 153 TC (p = 0.012) and ABCB1 3435 CT/TT (p = 0.034) genotypes predicted MC presence. Conclusion: These data could help clinicians to identify patients with higher probability to show MC extra hepatic complication.

Original language	English
Pages (from-to)	607-611
Number of pages	5
Journal	Pharmacogenomics
Volume	18
Issue number	7
DOIs	https://doi.org/10.2217/pgs-2016-0040
Publication status	Published - May 2017
Externally published	Yes

Keywords

ABCB1
HCV
HCV extra hepatic manifestation
NT5
cryoglobulin
pegylated interferon/ribavirin
pharmacogenetics SNPs

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/pgs-2016-0040

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@article{7f38ac5e123e4d478e3c5344bd12ce17,

title = "Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia",

abstract = "Aim: Mixed cryoglobulinemia (MC) is an extra hepatic hepatitis C virus related problem and different studies suggested genetics' role in predicting this complication. We evaluated the influence of SNPs in IL-28B, SLC29A1, SLC28A2, NT5C2, HNF4 and ABCB1 genes in MC prediction. Patients & methods: SNPs were evaluated through real-time PCR. Results: ABCB1 (gene encoding P-glycoprotein) 3435C>T SNP was associated with MC presence (p = 0.034): related to T allele carriers (CC vs CT/TT), we reached a p-value of 0.013. In the logistic regression analysis baseline viral load >600.000 IU/ml (p < 001), IL28B rs8099917/rs12979860 TT/CC (p < 0.001), NT5 (gene encoding for 5' nucleotidase) 153 TC (p = 0.012) and ABCB1 3435 CT/TT (p = 0.034) genotypes predicted MC presence. Conclusion: These data could help clinicians to identify patients with higher probability to show MC extra hepatic complication.",

keywords = "ABCB1, HCV, HCV extra hepatic manifestation, NT5, cryoglobulin, pegylated interferon/ribavirin, pharmacogenetics SNPs",

author = "Jessica Cusato and Lucio Boglione and {De Nicol{\`o}}, Amedeo and Cardellino, {Chiara Simona} and Chiara Carcieri and Giuseppe Cariti and {Di Perri}, Giovanni and Antonio D'Avolio",

note = "Publisher Copyright: {\textcopyright} 2017 Future Medicine Ltd.",

year = "2017",

month = may,

doi = "10.2217/pgs-2016-0040",

language = "English",

volume = "18",

pages = "607--611",

journal = "Pharmacogenomics",

issn = "1462-2416",

publisher = "Taylor and Francis Ltd.",

number = "7",

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TY - JOUR

T1 - Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia

AU - Cusato, Jessica

AU - Boglione, Lucio

AU - De Nicolò, Amedeo

AU - Cardellino, Chiara Simona

AU - Carcieri, Chiara

AU - Cariti, Giuseppe

AU - Di Perri, Giovanni

AU - D'Avolio, Antonio

PY - 2017/5

Y1 - 2017/5

N2 - Aim: Mixed cryoglobulinemia (MC) is an extra hepatic hepatitis C virus related problem and different studies suggested genetics' role in predicting this complication. We evaluated the influence of SNPs in IL-28B, SLC29A1, SLC28A2, NT5C2, HNF4 and ABCB1 genes in MC prediction. Patients & methods: SNPs were evaluated through real-time PCR. Results: ABCB1 (gene encoding P-glycoprotein) 3435C>T SNP was associated with MC presence (p = 0.034): related to T allele carriers (CC vs CT/TT), we reached a p-value of 0.013. In the logistic regression analysis baseline viral load >600.000 IU/ml (p < 001), IL28B rs8099917/rs12979860 TT/CC (p < 0.001), NT5 (gene encoding for 5' nucleotidase) 153 TC (p = 0.012) and ABCB1 3435 CT/TT (p = 0.034) genotypes predicted MC presence. Conclusion: These data could help clinicians to identify patients with higher probability to show MC extra hepatic complication.

AB - Aim: Mixed cryoglobulinemia (MC) is an extra hepatic hepatitis C virus related problem and different studies suggested genetics' role in predicting this complication. We evaluated the influence of SNPs in IL-28B, SLC29A1, SLC28A2, NT5C2, HNF4 and ABCB1 genes in MC prediction. Patients & methods: SNPs were evaluated through real-time PCR. Results: ABCB1 (gene encoding P-glycoprotein) 3435C>T SNP was associated with MC presence (p = 0.034): related to T allele carriers (CC vs CT/TT), we reached a p-value of 0.013. In the logistic regression analysis baseline viral load >600.000 IU/ml (p < 001), IL28B rs8099917/rs12979860 TT/CC (p < 0.001), NT5 (gene encoding for 5' nucleotidase) 153 TC (p = 0.012) and ABCB1 3435 CT/TT (p = 0.034) genotypes predicted MC presence. Conclusion: These data could help clinicians to identify patients with higher probability to show MC extra hepatic complication.

KW - ABCB1

KW - HCV

KW - HCV extra hepatic manifestation

KW - NT5

KW - cryoglobulin

KW - pegylated interferon/ribavirin

KW - pharmacogenetics SNPs

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U2 - 10.2217/pgs-2016-0040

DO - 10.2217/pgs-2016-0040

M3 - Article

SN - 1462-2416

VL - 18

SP - 607

EP - 611

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 7

ER -

Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia

Abstract

Keywords

UN SDGs

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