TY - JOUR
T1 - Permeate from cheese whey ultrafiltration is a source of milk oligosaccharides
AU - Barile, Daniela
AU - Tao, Nannan
AU - Lebrilla, Carlito B.
AU - Coisson, Jean Daniel
AU - Arlorio, Marco
AU - German, J. Bruce
N1 - Funding Information:
Funding for this research provided by the California Dairy Research Foundation, Dairy Management Incorporated, the University of California Discovery and the National Institutes of Health is gratefully acknowledged. The authors would like to thank Cora Morgan and Matthew Lange for critical reading of this paper.
PY - 2009/9
Y1 - 2009/9
N2 - Previously undescribed oligosaccharides in bovine cheese whey permeate were characterized by a combination of nanoelectrospray Fourier transform ion cyclotron resonance (nESI-FTICR) mass spectrometry and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance (MALDI-FTICR) mass spectrometry. Oligosaccharide composition was elucidated by collision-induced dissociation within the ICR cell. In addition to sialyllactose (the most abundant oligosaccharide in bovine colostrum), we identified 14 other oligosaccharides, half of which have the same composition of human milk oligosaccharides. These oligosaccharides could potentially be used as additives in infant formula and products for the pharmaceutical industry. Because whey permeate is a by-product from the production of whey protein concentrate (WPC) and is readily available, it is an attractive source of oligosaccharides for potential application in human nutrition.
AB - Previously undescribed oligosaccharides in bovine cheese whey permeate were characterized by a combination of nanoelectrospray Fourier transform ion cyclotron resonance (nESI-FTICR) mass spectrometry and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance (MALDI-FTICR) mass spectrometry. Oligosaccharide composition was elucidated by collision-induced dissociation within the ICR cell. In addition to sialyllactose (the most abundant oligosaccharide in bovine colostrum), we identified 14 other oligosaccharides, half of which have the same composition of human milk oligosaccharides. These oligosaccharides could potentially be used as additives in infant formula and products for the pharmaceutical industry. Because whey permeate is a by-product from the production of whey protein concentrate (WPC) and is readily available, it is an attractive source of oligosaccharides for potential application in human nutrition.
UR - https://www.scopus.com/pages/publications/67349260397
U2 - 10.1016/j.idairyj.2009.03.008
DO - 10.1016/j.idairyj.2009.03.008
M3 - Article
SN - 0958-6946
VL - 19
SP - 524
EP - 530
JO - International Dairy Journal
JF - International Dairy Journal
IS - 9
ER -