Paramagnetic water proton relaxation enhancement: From contrast agents in MRI to reagents for quantitative "in vitro" assays

Silvio Aime; Mauro Botta; Giuseppe Ermondi; Mauro Fasano; Enzo Terreno

doi:10.1016/0730-725X(92)90421-U

Paramagnetic water proton relaxation enhancement: From contrast agents in MRI to reagents for quantitative "in vitro" assays

Silvio Aime, Mauro Botta, Giuseppe Ermondi, Mauro Fasano, Enzo Terreno

Research output: Contribution to journal › Article › peer-review

Abstract

The use of stable complexes of paramagnetic metal ions as probes in analytical applications of the NMR technique is discussed. Two examples are given that involve the determination of the total Fe³⁺ content of human serum transferrin (Tf) and the extent of glycation of human serum albumin (HSA). The method is based on the measurement of the longitudinal water proton relaxation times, conveniently altered following a selective chemical interaction between the substrate and the paramagnetic probe.

Original language	English
Pages (from-to)	849-854
Number of pages	6
Journal	Magnetic Resonance Imaging
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/0730-725X(92)90421-U
Publication status	Published - 1992
Externally published	Yes

Keywords

Glycated albumin
Paramagnetic relaxation
Quantitative assays
Transferrin

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10.1016/0730-725X(92)90421-U

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author = "Silvio Aime and Mauro Botta and Giuseppe Ermondi and Mauro Fasano and Enzo Terreno",

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T1 - Paramagnetic water proton relaxation enhancement

T2 - From contrast agents in MRI to reagents for quantitative "in vitro" assays

AU - Aime, Silvio

AU - Botta, Mauro

AU - Ermondi, Giuseppe

AU - Fasano, Mauro

AU - Terreno, Enzo

PY - 1992

Y1 - 1992

N2 - The use of stable complexes of paramagnetic metal ions as probes in analytical applications of the NMR technique is discussed. Two examples are given that involve the determination of the total Fe3+ content of human serum transferrin (Tf) and the extent of glycation of human serum albumin (HSA). The method is based on the measurement of the longitudinal water proton relaxation times, conveniently altered following a selective chemical interaction between the substrate and the paramagnetic probe.

AB - The use of stable complexes of paramagnetic metal ions as probes in analytical applications of the NMR technique is discussed. Two examples are given that involve the determination of the total Fe3+ content of human serum transferrin (Tf) and the extent of glycation of human serum albumin (HSA). The method is based on the measurement of the longitudinal water proton relaxation times, conveniently altered following a selective chemical interaction between the substrate and the paramagnetic probe.

KW - Glycated albumin

KW - Paramagnetic relaxation

KW - Quantitative assays

KW - Transferrin

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U2 - 10.1016/0730-725X(92)90421-U

DO - 10.1016/0730-725X(92)90421-U

M3 - Article

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EP - 854

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 5

ER -

Paramagnetic water proton relaxation enhancement: From contrast agents in MRI to reagents for quantitative "in vitro" assays

Abstract

Keywords

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