Oligosaccharides Related to Tumor‐Associate Antigens. Part 4. Modeling of the terminal tetrasaccharide of an antigen recognized by the MBr1 antibody and of overlapping Di‐ and trisaccharide sequences

Lucio Toma; Diego Colombo; Fiamma Ronchetti; Luigi Panza; Giovanni Russo

doi:10.1002/hlca.19950780311

Oligosaccharides Related to Tumor‐Associate Antigens. Part 4. Modeling of the terminal tetrasaccharide of an antigen recognized by the MBr1 antibody and of overlapping Di‐ and trisaccharide sequences

Lucio Toma
, Diego Colombo
, Fiamma Ronchetti
, Luigi Panza
, Giovanni Russo

Research output: Contribution to journal › Article › peer-review

Abstract

The conformational space of the tetrasaccharide α‐L‐Fuc‐(1→2)‐β‐D‐Gal‐(1→3)‐β‐D‐GalNAc‐(1→3)‐α‐D‐GallPr (3) and of some overlapping di‐ and trisaccharide sequences was investigated with the aid of molecular‐mechanics energy minimizations, molecular‐dynamics simulations, and ¹H‐NMR analysis. These investigations suggested that in compound 3 a certain rigidity of the first two glycosidic linkages (Fuc‐Gal and Gal‐GalNAc) is combined with the flexibility of the third one (GalNAc‐Gal).

Original language	English
Pages (from-to)	636-646
Number of pages	11
Journal	Helvetica Chimica Acta
Volume	78
Issue number	3
DOIs	https://doi.org/10.1002/hlca.19950780311
Publication status	Published - 10 May 1995
Externally published	Yes

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@article{69e4d7ab7b4d4ef792918780e83c297f,

title = "Oligosaccharides Related to Tumor‐Associate Antigens. Part 4. Modeling of the terminal tetrasaccharide of an antigen recognized by the MBr1 antibody and of overlapping Di‐ and trisaccharide sequences",

abstract = "The conformational space of the tetrasaccharide α‐L‐Fuc‐(1→2)‐β‐D‐Gal‐(1→3)‐β‐D‐GalNAc‐(1→3)‐α‐D‐GallPr (3) and of some overlapping di‐ and trisaccharide sequences was investigated with the aid of molecular‐mechanics energy minimizations, molecular‐dynamics simulations, and 1H‐NMR analysis. These investigations suggested that in compound 3 a certain rigidity of the first two glycosidic linkages (Fuc‐Gal and Gal‐GalNAc) is combined with the flexibility of the third one (GalNAc‐Gal).",

author = "Lucio Toma and Diego Colombo and Fiamma Ronchetti and Luigi Panza and Giovanni Russo",

year = "1995",

month = may,

day = "10",

doi = "10.1002/hlca.19950780311",

language = "English",

volume = "78",

pages = "636--646",

journal = "Helvetica Chimica Acta",

issn = "0018-019X",

publisher = "Wiley-Blackwell",

number = "3",

}

Oligosaccharides Related to Tumor‐Associate Antigens. Part 4. Modeling of the terminal tetrasaccharide of an antigen recognized by the MBr1 antibody and of overlapping Di‐ and trisaccharide sequences. / Toma, Lucio; Colombo, Diego; Ronchetti, Fiamma et al.
In: Helvetica Chimica Acta, Vol. 78, No. 3, 10.05.1995, p. 636-646.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Oligosaccharides Related to Tumor‐Associate Antigens. Part 4. Modeling of the terminal tetrasaccharide of an antigen recognized by the MBr1 antibody and of overlapping Di‐ and trisaccharide sequences

AU - Toma, Lucio

AU - Colombo, Diego

AU - Ronchetti, Fiamma

AU - Panza, Luigi

AU - Russo, Giovanni

PY - 1995/5/10

Y1 - 1995/5/10

N2 - The conformational space of the tetrasaccharide α‐L‐Fuc‐(1→2)‐β‐D‐Gal‐(1→3)‐β‐D‐GalNAc‐(1→3)‐α‐D‐GallPr (3) and of some overlapping di‐ and trisaccharide sequences was investigated with the aid of molecular‐mechanics energy minimizations, molecular‐dynamics simulations, and 1H‐NMR analysis. These investigations suggested that in compound 3 a certain rigidity of the first two glycosidic linkages (Fuc‐Gal and Gal‐GalNAc) is combined with the flexibility of the third one (GalNAc‐Gal).

AB - The conformational space of the tetrasaccharide α‐L‐Fuc‐(1→2)‐β‐D‐Gal‐(1→3)‐β‐D‐GalNAc‐(1→3)‐α‐D‐GallPr (3) and of some overlapping di‐ and trisaccharide sequences was investigated with the aid of molecular‐mechanics energy minimizations, molecular‐dynamics simulations, and 1H‐NMR analysis. These investigations suggested that in compound 3 a certain rigidity of the first two glycosidic linkages (Fuc‐Gal and Gal‐GalNAc) is combined with the flexibility of the third one (GalNAc‐Gal).

UR - https://www.scopus.com/pages/publications/0029082603

U2 - 10.1002/hlca.19950780311

DO - 10.1002/hlca.19950780311

M3 - Article

SN - 0018-019X

VL - 78

SP - 636

EP - 646

JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

IS - 3

ER -

Oligosaccharides Related to Tumor‐Associate Antigens. Part 4. Modeling of the terminal tetrasaccharide of an antigen recognized by the MBr1 antibody and of overlapping Di‐ and trisaccharide sequences

Abstract

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