Nuclear Magnetic Relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation

Leonardo Lopiano; Mauro Fasano; Sabrina Giraudo; Giuseppe Digilio; Seymour H. Koenig; Elena Torre; Bruno Bergamasco; Silvio Aime

doi:10.1016/S0197-0186(00)00036-X

Nuclear Magnetic Relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation

Leonardo Lopiano
, Mauro Fasano
, Sabrina Giraudo
, Giuseppe Digilio
, Seymour H. Koenig
, Elena Torre
, Bruno Bergamasco
, Silvio Aime

Research output: Contribution to journal › Article › peer-review

Abstract

Nuclear Magnetic Relaxation field-cycling relaxometry is a technique, able to report on water mobility in tissues. By means of this technique, post-mortem specimens from both controls and idiopathic Parkinson's disease patients have been investigated. Results show different relaxometric behavior between the groups, which is consistent with protein aggregation in Parkinson's disease specimens. Copyright (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	331-336
Number of pages	6
Journal	Neurochemistry International
Volume	37
Issue number	4
DOIs	https://doi.org/10.1016/S0197-0186(00)00036-X
Publication status	Published - 1 Oct 2000
Externally published	Yes

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10.1016/S0197-0186(00)00036-X

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title = "Nuclear Magnetic Relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation",

abstract = "Nuclear Magnetic Relaxation field-cycling relaxometry is a technique, able to report on water mobility in tissues. By means of this technique, post-mortem specimens from both controls and idiopathic Parkinson's disease patients have been investigated. Results show different relaxometric behavior between the groups, which is consistent with protein aggregation in Parkinson's disease specimens. Copyright (C) 2000 Elsevier Science Ltd.",

author = "Leonardo Lopiano and Mauro Fasano and Sabrina Giraudo and Giuseppe Digilio and Koenig, \{Seymour H.\} and Elena Torre and Bruno Bergamasco and Silvio Aime",

note = "Funding Information: S. G. thanks the Italian Parkinson{\textquoteright}s Association (AIP) for a postdoctoral fellowship. The authors acknowledge the Nederlandse Hersenbank, Amsterdam, for supplying pathological tissue specimens and control group. ",

year = "2000",

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doi = "10.1016/S0197-0186(00)00036-X",

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T1 - Nuclear Magnetic Relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation

AU - Lopiano, Leonardo

AU - Fasano, Mauro

AU - Giraudo, Sabrina

AU - Digilio, Giuseppe

AU - Koenig, Seymour H.

AU - Torre, Elena

AU - Bergamasco, Bruno

AU - Aime, Silvio

N1 - Funding Information: S. G. thanks the Italian Parkinson’s Association (AIP) for a postdoctoral fellowship. The authors acknowledge the Nederlandse Hersenbank, Amsterdam, for supplying pathological tissue specimens and control group.

PY - 2000/10/1

Y1 - 2000/10/1

N2 - Nuclear Magnetic Relaxation field-cycling relaxometry is a technique, able to report on water mobility in tissues. By means of this technique, post-mortem specimens from both controls and idiopathic Parkinson's disease patients have been investigated. Results show different relaxometric behavior between the groups, which is consistent with protein aggregation in Parkinson's disease specimens. Copyright (C) 2000 Elsevier Science Ltd.

AB - Nuclear Magnetic Relaxation field-cycling relaxometry is a technique, able to report on water mobility in tissues. By means of this technique, post-mortem specimens from both controls and idiopathic Parkinson's disease patients have been investigated. Results show different relaxometric behavior between the groups, which is consistent with protein aggregation in Parkinson's disease specimens. Copyright (C) 2000 Elsevier Science Ltd.

UR - https://www.scopus.com/pages/publications/0034309848

U2 - 10.1016/S0197-0186(00)00036-X

DO - 10.1016/S0197-0186(00)00036-X

M3 - Article

SN - 0197-0186

VL - 37

SP - 331

EP - 336

JO - Neurochemistry International

JF - Neurochemistry International

IS - 4

ER -

Nuclear Magnetic Relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation

Abstract

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