No association of DPP6 with amyotrophic lateral sclerosis in an Italian population

I Fogh; Sandra D'ALFONSO; C Gellera; A Ratti; C Cereda; S Penco; Lucia CORRADO; G Soraru; B Castellotti; C Tiloca; S Gagliardi; L Cozzi; Lupton MK; N Ticozzi; L Mazzini; Shaw CE; Chalabi A Al; J Powell; V. Silani

doi:10.1016/j.neurobiolaging.2009.05.014

No association of DPP6 with amyotrophic lateral sclerosis in an Italian population

I Fogh
, Sandra D'ALFONSO
, C Gellera
, A Ratti
, C Cereda
, S Penco
, Lucia CORRADO
, G Soraru
, B Castellotti
, C Tiloca
, S Gagliardi
, L Cozzi
, Lupton MK
, N Ticozzi
, L Mazzini
, Shaw CE
, Chalabi A Al
, J Powell
, V. Silani

Department of Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P= 0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.

Original language	English
Pages (from-to)	966-967
Number of pages	2
Journal	Neurobiology of Aging
Volume	32
Issue number	5
DOIs	https://doi.org/10.1016/j.neurobiolaging.2009.05.014
Publication status	Published - 2011

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10.1016/j.neurobiolaging.2009.05.014

http://hdl.handle.net/11579/14690

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Fogh, I., D'ALFONSO, S., Gellera, C., Ratti, A., Cereda, C., Penco, S., CORRADO, L., Soraru, G., Castellotti, B., Tiloca, C., Gagliardi, S., Cozzi, L., MK, L., Ticozzi, N., Mazzini, L., CE, S., Al, C. A., Powell, J., & Silani, V. (2011). No association of DPP6 with amyotrophic lateral sclerosis in an Italian population. Neurobiology of Aging, 32(5), 966-967. https://doi.org/10.1016/j.neurobiolaging.2009.05.014

@article{621848a1098a402c94c4d2a0faef1833,

title = "No association of DPP6 with amyotrophic lateral sclerosis in an Italian population",

abstract = "We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P= 0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.",

author = "I Fogh and Sandra D'ALFONSO and C Gellera and A Ratti and C Cereda and S Penco and Lucia CORRADO and G Soraru and B Castellotti and C Tiloca and S Gagliardi and L Cozzi and Lupton MK and N Ticozzi and L Mazzini and Shaw CE and Al, \{Chalabi A\} and J Powell and V. Silani",

year = "2011",

doi = "10.1016/j.neurobiolaging.2009.05.014",

language = "English",

volume = "32",

pages = "966--967",

journal = "Neurobiology of Aging",

issn = "0197-4580",

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}

Fogh, I, D'ALFONSO, S, Gellera, C, Ratti, A, Cereda, C, Penco, S, CORRADO, L, Soraru, G, Castellotti, B, Tiloca, C, Gagliardi, S, Cozzi, L, MK, L, Ticozzi, N, Mazzini, L, CE, S, Al, CA, Powell, J & Silani, V 2011, 'No association of DPP6 with amyotrophic lateral sclerosis in an Italian population', Neurobiology of Aging, vol. 32, no. 5, pp. 966-967. https://doi.org/10.1016/j.neurobiolaging.2009.05.014

TY - JOUR

T1 - No association of DPP6 with amyotrophic lateral sclerosis in an Italian population

AU - Fogh, I

AU - D'ALFONSO, Sandra

AU - Gellera, C

AU - Ratti, A

AU - Cereda, C

AU - Penco, S

AU - CORRADO, Lucia

AU - Soraru, G

AU - Castellotti, B

AU - Tiloca, C

AU - Gagliardi, S

AU - Cozzi, L

AU - MK, Lupton

AU - Ticozzi, N

AU - Mazzini, L

AU - CE, Shaw

AU - Al, Chalabi A

AU - Powell, J

AU - Silani, V.

PY - 2011

Y1 - 2011

N2 - We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P= 0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.

AB - We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P= 0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.

UR - https://iris.uniupo.it/handle/11579/14690

U2 - 10.1016/j.neurobiolaging.2009.05.014

DO - 10.1016/j.neurobiolaging.2009.05.014

M3 - Article

SN - 0197-4580

VL - 32

SP - 966

EP - 967

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 5

ER -

No association of DPP6 with amyotrophic lateral sclerosis in an Italian population

Abstract

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