New insights on low vitamin D plasma concentration as a potential cardiovascular risk factor

Research output: Contribution to journalReview articlepeer-review

Abstract

The role of Vitamin D hormone in human health and disease is still debated. Recently, growing attention has been paid to its putative role in cardiovascular system homeostasis with several studies that suggested a correlation between low vitamin D levels and increased cardiovascular risk. Several mechanisms are involved in the development of cardiovascular diseases: systemic inflammation, endothelial dysfunction, arterial hypertension and insulin resistance. In the present paper, we have revised the current literature supporting a role for vitamin D in the development of these pathogenetic processes. Finally, we have evaluated the current evidence linking vitamin D to atherosclerosis and its natural consequence, cardiovascular diseases.

Original languageEnglish
Pages (from-to)261-278
Number of pages18
JournalOpen Rheumatology Journal
Volume12
DOIs
Publication statusPublished - 2018

Keywords

  • Atherosclerosis
  • Cardiovascular diseases
  • Cardiovascular risk
  • Inflammation
  • Insulin resistance
  • Vitamin D

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