New insights into the redox chemistry of ruthenium metallopharmaceuticals: The electrochemical behaviour of [LH][trans-RuIIICl4L 2] (L = imidazole or indazole) complexes

Mauro Ravera, Claudio Cassino, Sara Baracco, Domenico Osella

Research output: Contribution to journalArticlepeer-review

Abstract

Here we report the findings from a study on the electrochemical behaviour of two RuIII complexes [LH][trans-RuIIICl 4L2] (L = imidazole, ICR, or indazole, IndCR) in aqueous solution at different pH values. An electrochemically reversible and chemically quasi-reversible one-electron reduction is observed for both compounds. Despite the similarity of the structures, the fate of the electrogenerated Ru II species is different; in the case of ICR, imidazole, followed by a chloride ion, is released as the consequence of the reduction, while for IndCR two subsequent water for chloride substitutions take place. Our measurements suggests that the RuIII complexes under study may serve as pro-drugs, being activated by reduction in a suitable aqueous environment and, therefore, binding biomolecules more rapidly.

Original languageEnglish
Pages (from-to)740-746
Number of pages7
JournalEuropean Journal of Inorganic Chemistry
Issue number4
DOIs
Publication statusPublished - 20 Feb 2006

Keywords

  • Antitumor agents
  • Electrochemistry
  • Redox chemistry
  • Ruthenium

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