Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma

V. Sorbello; G. Ciprandi; A. Di Stefano; G. M. Massaglia; G. Favatà; S. Conticello; M. Malerba; G. Folkerts; M. Profita; G. Rolla; F. L.M. Ricciardolo

doi:10.1111/all.12547

Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma

V. Sorbello, G. Ciprandi, A. Di Stefano, G. M. Massaglia, G. Favatà, S. Conticello, M. Malerba, G. Folkerts, M. Profita, G. Rolla, F. L.M. Ricciardolo

Research output: Contribution to journal › Article › peer-review

Abstract

Severe asthma (SA) is associated with neutrophil recruitment and T helper (T_H)17 chemokine overexpression in bronchial biopsies. We aimed to evaluate IL-17A and IL-17F expression in nasal/bronchial lamina propria of atopic mild-to-severe asthmatics and controls in relation to neutrophilia and asthma exacerbations. Cryostat sections of nasal/bronchial biopsies obtained from 14 SA and 14 mild asthma (MA) stable atopic patients with rhinitis, and seven healthy controls were analyzed by immunohistochemistry for neutrophils, IL-17A and IL-17F expression. Atopic SA showed an increase in asthma exacerbations number, IL-17F and IL-17A expression in nasal/bronchial lamina propria compared to MA and controls, and a higher expression of bronchial neutrophils in SA compared to MA and controls. In all asthmatics, significant relationships were found between bronchial IL-17F and neutrophils/FEV₁, nasal IL-17F and bronchial neutrophil/IL-17 markers and between the latter and exacerbations, suggesting that nasal IL-17F might be informative on bronchial IL17-driven neutrophilia in atopic SA.

Original language	English
Pages (from-to)	236-240
Number of pages	5
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	70
Issue number	2
DOIs	https://doi.org/10.1111/all.12547
Publication status	Published - 1 Feb 2015
Externally published	Yes

Keywords

IL-17
asthma
bronchial biopsy
nasal biopsy
neutrophils

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10.1111/all.12547

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Sorbello, V., Ciprandi, G., Di Stefano, A., Massaglia, G. M., Favatà, G., Conticello, S., Malerba, M., Folkerts, G., Profita, M., Rolla, G., & Ricciardolo, F. L. M. (2015). Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma. Allergy: European Journal of Allergy and Clinical Immunology, 70(2), 236-240. https://doi.org/10.1111/all.12547

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title = "Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma",

abstract = "Severe asthma (SA) is associated with neutrophil recruitment and T helper (TH)17 chemokine overexpression in bronchial biopsies. We aimed to evaluate IL-17A and IL-17F expression in nasal/bronchial lamina propria of atopic mild-to-severe asthmatics and controls in relation to neutrophilia and asthma exacerbations. Cryostat sections of nasal/bronchial biopsies obtained from 14 SA and 14 mild asthma (MA) stable atopic patients with rhinitis, and seven healthy controls were analyzed by immunohistochemistry for neutrophils, IL-17A and IL-17F expression. Atopic SA showed an increase in asthma exacerbations number, IL-17F and IL-17A expression in nasal/bronchial lamina propria compared to MA and controls, and a higher expression of bronchial neutrophils in SA compared to MA and controls. In all asthmatics, significant relationships were found between bronchial IL-17F and neutrophils/FEV1, nasal IL-17F and bronchial neutrophil/IL-17 markers and between the latter and exacerbations, suggesting that nasal IL-17F might be informative on bronchial IL17-driven neutrophilia in atopic SA.",

keywords = "IL-17, asthma, bronchial biopsy, nasal biopsy, neutrophils",

author = "V. Sorbello and G. Ciprandi and {Di Stefano}, A. and Massaglia, {G. M.} and G. Favat{\`a} and S. Conticello and M. Malerba and G. Folkerts and M. Profita and G. Rolla and Ricciardolo, {F. L.M.}",

note = "Publisher Copyright: {\textcopyright} 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2015",

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doi = "10.1111/all.12547",

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Sorbello, V, Ciprandi, G, Di Stefano, A, Massaglia, GM, Favatà, G, Conticello, S, Malerba, M, Folkerts, G, Profita, M, Rolla, G & Ricciardolo, FLM 2015, 'Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma', Allergy: European Journal of Allergy and Clinical Immunology, vol. 70, no. 2, pp. 236-240. https://doi.org/10.1111/all.12547

TY - JOUR

T1 - Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma

AU - Sorbello, V.

AU - Ciprandi, G.

AU - Di Stefano, A.

AU - Massaglia, G. M.

AU - Favatà, G.

AU - Conticello, S.

AU - Malerba, M.

AU - Folkerts, G.

AU - Profita, M.

AU - Rolla, G.

AU - Ricciardolo, F. L.M.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Severe asthma (SA) is associated with neutrophil recruitment and T helper (TH)17 chemokine overexpression in bronchial biopsies. We aimed to evaluate IL-17A and IL-17F expression in nasal/bronchial lamina propria of atopic mild-to-severe asthmatics and controls in relation to neutrophilia and asthma exacerbations. Cryostat sections of nasal/bronchial biopsies obtained from 14 SA and 14 mild asthma (MA) stable atopic patients with rhinitis, and seven healthy controls were analyzed by immunohistochemistry for neutrophils, IL-17A and IL-17F expression. Atopic SA showed an increase in asthma exacerbations number, IL-17F and IL-17A expression in nasal/bronchial lamina propria compared to MA and controls, and a higher expression of bronchial neutrophils in SA compared to MA and controls. In all asthmatics, significant relationships were found between bronchial IL-17F and neutrophils/FEV1, nasal IL-17F and bronchial neutrophil/IL-17 markers and between the latter and exacerbations, suggesting that nasal IL-17F might be informative on bronchial IL17-driven neutrophilia in atopic SA.

AB - Severe asthma (SA) is associated with neutrophil recruitment and T helper (TH)17 chemokine overexpression in bronchial biopsies. We aimed to evaluate IL-17A and IL-17F expression in nasal/bronchial lamina propria of atopic mild-to-severe asthmatics and controls in relation to neutrophilia and asthma exacerbations. Cryostat sections of nasal/bronchial biopsies obtained from 14 SA and 14 mild asthma (MA) stable atopic patients with rhinitis, and seven healthy controls were analyzed by immunohistochemistry for neutrophils, IL-17A and IL-17F expression. Atopic SA showed an increase in asthma exacerbations number, IL-17F and IL-17A expression in nasal/bronchial lamina propria compared to MA and controls, and a higher expression of bronchial neutrophils in SA compared to MA and controls. In all asthmatics, significant relationships were found between bronchial IL-17F and neutrophils/FEV1, nasal IL-17F and bronchial neutrophil/IL-17 markers and between the latter and exacerbations, suggesting that nasal IL-17F might be informative on bronchial IL17-driven neutrophilia in atopic SA.

KW - IL-17

KW - asthma

KW - bronchial biopsy

KW - nasal biopsy

KW - neutrophils

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U2 - 10.1111/all.12547

DO - 10.1111/all.12547

M3 - Article

SN - 0105-4538

VL - 70

SP - 236

EP - 240

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 2

ER -

Nasal IL-17F is related to bronchial IL-17F/neutrophilia and exacerbations in stable atopic severe asthma

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Keywords

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