NANOPARTICLE OF THE CORE-SHELL TYPE SUITABLE FOR DELIVERING THERAPEUTIC OLIGONUCLEOTIDES TO TARGET TISSUES AND THE USE THEREOF FOR THE PREPARATION OF A MEDICAMENT FOR TREATING DUCHENNE MUSCULAR DYSTROPHY

FERLINI Alessandra; MEDICI Alessandro; PERRONE Daniela; RIMESSI Paola; TONDELLI Luisa; Michele LAUS; Katia SPARNACCI

NANOPARTICLE OF THE CORE-SHELL TYPE SUITABLE FOR DELIVERING THERAPEUTIC OLIGONUCLEOTIDES TO TARGET TISSUES AND THE USE THEREOF FOR THE PREPARATION OF A MEDICAMENT FOR TREATING DUCHENNE MUSCULAR DYSTROPHY

FERLINI Alessandra (Inventor)
, MEDICI Alessandro (Inventor)
, PERRONE Daniela (Inventor)
, RIMESSI Paola (Inventor)
, TONDELLI Luisa (Inventor)
, Michele LAUS (Inventor)
, Katia SPARNACCI (Inventor)

Department of Science and Technological Innovation

Research output: Patent

Abstract

A nanoparticle of the core-shell type is described, which is suitable for delivering therapeu not tic oligonucleotides into muscle fibres, particularly antisense oligoribonucleotides capable of restoring, in all or in part, the expression of the dystrophin protein by the exon skipping mecha not nism, and thus effective in the treatment of Duchenne muscular dystrophy. Moreover, a nanoparti- cle/oligonucleotide complex effective in the treatment of Duchenne muscular dystrophy is de not scribed

Original language	English
Patent number	WO/2011/045747
Publication status	Published - 1 Jan 2010

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http://hdl.handle.net/11579/23687

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Alessandra, FERLINI., Alessandro, MEDICI., Daniela, PERRONE., Paola, RIMESSI., Luisa, TONDELLI., LAUS, M., & SPARNACCI, K. (2010). NANOPARTICLE OF THE CORE-SHELL TYPE SUITABLE FOR DELIVERING THERAPEUTIC OLIGONUCLEOTIDES TO TARGET TISSUES AND THE USE THEREOF FOR THE PREPARATION OF A MEDICAMENT FOR TREATING DUCHENNE MUSCULAR DYSTROPHY. (Patent No. WO/2011/045747). http://hdl.handle.net/11579/23687

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title = "NANOPARTICLE OF THE CORE-SHELL TYPE SUITABLE FOR DELIVERING THERAPEUTIC OLIGONUCLEOTIDES TO TARGET TISSUES AND THE USE THEREOF FOR THE PREPARATION OF A MEDICAMENT FOR TREATING DUCHENNE MUSCULAR DYSTROPHY",

abstract = "A nanoparticle of the core-shell type is described, which is suitable for delivering therapeu not tic oligonucleotides into muscle fibres, particularly antisense oligoribonucleotides capable of restoring, in all or in part, the expression of the dystrophin protein by the exon skipping mecha not nism, and thus effective in the treatment of Duchenne muscular dystrophy. Moreover, a nanoparti- cle/oligonucleotide complex effective in the treatment of Duchenne muscular dystrophy is de not scribed",

author = "FERLINI Alessandra and MEDICI Alessandro and PERRONE Daniela and RIMESSI Paola and TONDELLI Luisa and Michele LAUS and Katia SPARNACCI",

year = "2010",

month = jan,

day = "1",

language = "English",

type = "Patent",

note = "WO/2011/045747",

}

Alessandra, FERLINI, Alessandro, MEDICI, Daniela, PERRONE, Paola, RIMESSI, Luisa, TONDELLI, LAUS, M & SPARNACCI, K Jan. 01 2010, NANOPARTICLE OF THE CORE-SHELL TYPE SUITABLE FOR DELIVERING THERAPEUTIC OLIGONUCLEOTIDES TO TARGET TISSUES AND THE USE THEREOF FOR THE PREPARATION OF A MEDICAMENT FOR TREATING DUCHENNE MUSCULAR DYSTROPHY, Patent No. WO/2011/045747. <http://hdl.handle.net/11579/23687>

TY - PAT

T1 - NANOPARTICLE OF THE CORE-SHELL TYPE SUITABLE FOR DELIVERING THERAPEUTIC OLIGONUCLEOTIDES TO TARGET TISSUES AND THE USE THEREOF FOR THE PREPARATION OF A MEDICAMENT FOR TREATING DUCHENNE MUSCULAR DYSTROPHY

AU - Alessandra, FERLINI

AU - Alessandro, MEDICI

AU - Daniela, PERRONE

AU - Paola, RIMESSI

AU - Luisa, TONDELLI

AU - LAUS, Michele

AU - SPARNACCI, Katia

PY - 2010/1/1

Y1 - 2010/1/1

N2 - A nanoparticle of the core-shell type is described, which is suitable for delivering therapeu not tic oligonucleotides into muscle fibres, particularly antisense oligoribonucleotides capable of restoring, in all or in part, the expression of the dystrophin protein by the exon skipping mecha not nism, and thus effective in the treatment of Duchenne muscular dystrophy. Moreover, a nanoparti- cle/oligonucleotide complex effective in the treatment of Duchenne muscular dystrophy is de not scribed

AB - A nanoparticle of the core-shell type is described, which is suitable for delivering therapeu not tic oligonucleotides into muscle fibres, particularly antisense oligoribonucleotides capable of restoring, in all or in part, the expression of the dystrophin protein by the exon skipping mecha not nism, and thus effective in the treatment of Duchenne muscular dystrophy. Moreover, a nanoparti- cle/oligonucleotide complex effective in the treatment of Duchenne muscular dystrophy is de not scribed

UR - https://iris.uniupo.it/handle/11579/23687

M3 - Patent

M1 - WO/2011/045747

ER -

NANOPARTICLE OF THE CORE-SHELL TYPE SUITABLE FOR DELIVERING THERAPEUTIC OLIGONUCLEOTIDES TO TARGET TISSUES AND THE USE THEREOF FOR THE PREPARATION OF A MEDICAMENT FOR TREATING DUCHENNE MUSCULAR DYSTROPHY

Abstract

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