Muscarinic cholinergic receptor binding in rat mast cells

E. Masini; R. Fantozzi; P. Blandina; S. Brunelleschi; P. F. Mannaioni

doi:10.1007/BF01971484

Muscarinic cholinergic receptor binding in rat mast cells

E. Masini
, R. Fantozzi
, P. Blandina
, S. Brunelleschi
, P. F. Mannaioni

Research output: Contribution to journal › Article › peer-review

Abstract

Specific [³H]-QNB binding was present in isolated, purified, intact rat mast cells and in crude membrane preparations. The binding is saturable, time- and temperature-dependent. Cholinergic agents inhibit selectively the binding: atropine is the most effective of the antagonists while oxotremorine is the most potent of the muscarinic agonists. It is concluded that rat mast cells are provided with muscarinic cholinergic receptors.

Original language	English
Pages (from-to)	327-332
Number of pages	6
Journal	Agents and Actions
Volume	13
Issue number	4
DOIs	https://doi.org/10.1007/BF01971484
Publication status	Published - Jul 1983
Externally published	Yes

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10.1007/BF01971484

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title = "Muscarinic cholinergic receptor binding in rat mast cells",

abstract = "Specific [3H]-QNB binding was present in isolated, purified, intact rat mast cells and in crude membrane preparations. The binding is saturable, time- and temperature-dependent. Cholinergic agents inhibit selectively the binding: atropine is the most effective of the antagonists while oxotremorine is the most potent of the muscarinic agonists. It is concluded that rat mast cells are provided with muscarinic cholinergic receptors.",

author = "E. Masini and R. Fantozzi and P. Blandina and S. Brunelleschi and Mannaioni, \{P. F.\}",

year = "1983",

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language = "English",

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T1 - Muscarinic cholinergic receptor binding in rat mast cells

AU - Masini, E.

AU - Fantozzi, R.

AU - Blandina, P.

AU - Brunelleschi, S.

AU - Mannaioni, P. F.

PY - 1983/7

Y1 - 1983/7

N2 - Specific [3H]-QNB binding was present in isolated, purified, intact rat mast cells and in crude membrane preparations. The binding is saturable, time- and temperature-dependent. Cholinergic agents inhibit selectively the binding: atropine is the most effective of the antagonists while oxotremorine is the most potent of the muscarinic agonists. It is concluded that rat mast cells are provided with muscarinic cholinergic receptors.

AB - Specific [3H]-QNB binding was present in isolated, purified, intact rat mast cells and in crude membrane preparations. The binding is saturable, time- and temperature-dependent. Cholinergic agents inhibit selectively the binding: atropine is the most effective of the antagonists while oxotremorine is the most potent of the muscarinic agonists. It is concluded that rat mast cells are provided with muscarinic cholinergic receptors.

UR - https://www.scopus.com/pages/publications/0020629751

U2 - 10.1007/BF01971484

DO - 10.1007/BF01971484

M3 - Article

SN - 0065-4299

VL - 13

SP - 327

EP - 332

JO - Agents and Actions

JF - Agents and Actions

IS - 4

ER -

Muscarinic cholinergic receptor binding in rat mast cells

Abstract

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