Multiple sclerosis progression is not associated with birth timing in Italy

Ausiliatrice Lucenti; Stefania Galimberti; Nadia Barizzone; Paola Naldi; Giancarlo Comi; Filippo Martinelli Boneschi; Sandra D'Alfonso; Maurizio A. Leone

doi:10.1016/j.jns.2014.08.021

Multiple sclerosis progression is not associated with birth timing in Italy

Ausiliatrice Lucenti
, Stefania Galimberti
, Nadia Barizzone
, Paola Naldi
, Giancarlo Comi
, Filippo Martinelli Boneschi
, Sandra D'Alfonso
, Maurizio A. Leone

Department of Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Background Month of birth has been associated in some studies with the susceptibility to develop Multiple Sclerosis (MS). However, only few studies have evaluated whether birth timing also affects disease progression.

Objectives To assess whether season and month of birth are associated with disease progression in a large cohort of Italian patients.

Methods Quantile regression was used to analyze the impact of each month and season of birth with all the others combined on the median Multiple Sclerosis Severity Score of 1866 MS patients.

Results No significant temporal trend was found after adjustment for multiple comparisons.

Conclusions Birth timing showed no association with MS progression in Italian patients.

Original language	English
Pages (from-to)	194-196
Number of pages	3
Journal	Journal of the Neurological Sciences
Volume	346
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2014.08.021
Publication status	Published - 15 Nov 2014

Keywords

Month of birth
Multiple sclerosis
Progression
Season

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10.1016/j.jns.2014.08.021

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@article{99c9490f204449d9a6c27ae78972cb71,

title = "Multiple sclerosis progression is not associated with birth timing in Italy",

abstract = "Background Month of birth has been associated in some studies with the susceptibility to develop Multiple Sclerosis (MS). However, only few studies have evaluated whether birth timing also affects disease progression.Objectives To assess whether season and month of birth are associated with disease progression in a large cohort of Italian patients.Methods Quantile regression was used to analyze the impact of each month and season of birth with all the others combined on the median Multiple Sclerosis Severity Score of 1866 MS patients.Results No significant temporal trend was found after adjustment for multiple comparisons.Conclusions Birth timing showed no association with MS progression in Italian patients.",

keywords = "Month of birth, Multiple sclerosis, Progression, Season",

author = "Ausiliatrice Lucenti and Stefania Galimberti and Nadia Barizzone and Paola Naldi and Giancarlo Comi and \{Martinelli Boneschi\}, Filippo and Sandra D'Alfonso and Leone, \{Maurizio A.\}",

year = "2014",

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doi = "10.1016/j.jns.2014.08.021",

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T1 - Multiple sclerosis progression is not associated with birth timing in Italy

AU - Lucenti, Ausiliatrice

AU - Galimberti, Stefania

AU - Barizzone, Nadia

AU - Naldi, Paola

AU - Comi, Giancarlo

AU - Martinelli Boneschi, Filippo

AU - D'Alfonso, Sandra

AU - Leone, Maurizio A.

PY - 2014/11/15

Y1 - 2014/11/15

N2 - Background Month of birth has been associated in some studies with the susceptibility to develop Multiple Sclerosis (MS). However, only few studies have evaluated whether birth timing also affects disease progression.Objectives To assess whether season and month of birth are associated with disease progression in a large cohort of Italian patients.Methods Quantile regression was used to analyze the impact of each month and season of birth with all the others combined on the median Multiple Sclerosis Severity Score of 1866 MS patients.Results No significant temporal trend was found after adjustment for multiple comparisons.Conclusions Birth timing showed no association with MS progression in Italian patients.

AB - Background Month of birth has been associated in some studies with the susceptibility to develop Multiple Sclerosis (MS). However, only few studies have evaluated whether birth timing also affects disease progression.Objectives To assess whether season and month of birth are associated with disease progression in a large cohort of Italian patients.Methods Quantile regression was used to analyze the impact of each month and season of birth with all the others combined on the median Multiple Sclerosis Severity Score of 1866 MS patients.Results No significant temporal trend was found after adjustment for multiple comparisons.Conclusions Birth timing showed no association with MS progression in Italian patients.

KW - Month of birth

KW - Multiple sclerosis

KW - Progression

KW - Season

UR - https://www.scopus.com/pages/publications/84910128472

U2 - 10.1016/j.jns.2014.08.021

DO - 10.1016/j.jns.2014.08.021

M3 - Article

SN - 0022-510X

VL - 346

SP - 194

EP - 196

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

IS - 1-2

ER -

Multiple sclerosis progression is not associated with birth timing in Italy

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Keywords

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