Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features

Ignazia Prigione; Elio Castagnola; Luisa Imberti; Claudio Gambini; Luigi Gradoni; Umberto Dianzani; Ugo Ramenghi; Francesca Giacopelli; Alessandro Moretta; Lorenzo Moretta; Alessandro Plebani; Alain Fischer; Vito Pistoia

doi:10.1097/INF.0b013e318185513d

Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features

Ignazia Prigione
, Elio Castagnola
, Luisa Imberti
, Claudio Gambini
, Luigi Gradoni
, Umberto Dianzani
, Ugo Ramenghi
, Francesca Giacopelli
, Alessandro Moretta
, Lorenzo Moretta
, Alessandro Plebani
, Alain Fischer
, Vito Pistoia

Department of Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

An adolescent with idiopathic CD4 lymphocytopenia suffered from 4 visceral leishmaniasis relapses despite appropriate treatment. CD8 lymphocytopenia and abnormal expansion of TCRαβ, CD4^-, CD8^- cells were consistently detected together with reduced export of mature T cells from thymus. This novel form of idiopathic CD4⁺ lymphocytopenia may predispose to multiple visceral leishmaniasis relapses.

Original language	English
Pages (from-to)	161-163
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	28
Issue number	2
DOIs	https://doi.org/10.1097/INF.0b013e318185513d
Publication status	Published - Feb 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Immune deficiency
Relapsing visceral leishmaniasis

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10.1097/INF.0b013e318185513d

Cite this

Prigione, I., Castagnola, E., Imberti, L., Gambini, C., Gradoni, L., Dianzani, U., Ramenghi, U., Giacopelli, F., Moretta, A., Moretta, L., Plebani, A., Fischer, A., & Pistoia, V. (2009). Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features. Pediatric Infectious Disease Journal, 28(2), 161-163. https://doi.org/10.1097/INF.0b013e318185513d

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title = "Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features",

abstract = "An adolescent with idiopathic CD4 lymphocytopenia suffered from 4 visceral leishmaniasis relapses despite appropriate treatment. CD8 lymphocytopenia and abnormal expansion of TCRαβ, CD4-, CD8- cells were consistently detected together with reduced export of mature T cells from thymus. This novel form of idiopathic CD4+ lymphocytopenia may predispose to multiple visceral leishmaniasis relapses.",

keywords = "Immune deficiency, Relapsing visceral leishmaniasis",

author = "Ignazia Prigione and Elio Castagnola and Luisa Imberti and Claudio Gambini and Luigi Gradoni and Umberto Dianzani and Ugo Ramenghi and Francesca Giacopelli and Alessandro Moretta and Lorenzo Moretta and Alessandro Plebani and Alain Fischer and Vito Pistoia",

year = "2009",

month = feb,

doi = "10.1097/INF.0b013e318185513d",

language = "English",

volume = "28",

pages = "161--163",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

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Prigione, I, Castagnola, E, Imberti, L, Gambini, C, Gradoni, L, Dianzani, U, Ramenghi, U, Giacopelli, F, Moretta, A, Moretta, L, Plebani, A, Fischer, A & Pistoia, V 2009, 'Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features', Pediatric Infectious Disease Journal, vol. 28, no. 2, pp. 161-163. https://doi.org/10.1097/INF.0b013e318185513d

TY - JOUR

T1 - Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features

AU - Prigione, Ignazia

AU - Castagnola, Elio

AU - Imberti, Luisa

AU - Gambini, Claudio

AU - Gradoni, Luigi

AU - Dianzani, Umberto

AU - Ramenghi, Ugo

AU - Giacopelli, Francesca

AU - Moretta, Alessandro

AU - Moretta, Lorenzo

AU - Plebani, Alessandro

AU - Fischer, Alain

AU - Pistoia, Vito

PY - 2009/2

Y1 - 2009/2

N2 - An adolescent with idiopathic CD4 lymphocytopenia suffered from 4 visceral leishmaniasis relapses despite appropriate treatment. CD8 lymphocytopenia and abnormal expansion of TCRαβ, CD4-, CD8- cells were consistently detected together with reduced export of mature T cells from thymus. This novel form of idiopathic CD4+ lymphocytopenia may predispose to multiple visceral leishmaniasis relapses.

AB - An adolescent with idiopathic CD4 lymphocytopenia suffered from 4 visceral leishmaniasis relapses despite appropriate treatment. CD8 lymphocytopenia and abnormal expansion of TCRαβ, CD4-, CD8- cells were consistently detected together with reduced export of mature T cells from thymus. This novel form of idiopathic CD4+ lymphocytopenia may predispose to multiple visceral leishmaniasis relapses.

KW - Immune deficiency

KW - Relapsing visceral leishmaniasis

UR - https://www.scopus.com/pages/publications/61949276262

U2 - 10.1097/INF.0b013e318185513d

DO - 10.1097/INF.0b013e318185513d

M3 - Article

SN - 0891-3668

VL - 28

SP - 161

EP - 163

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 2

ER -

Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ Lymphocytopenia associated with novel immunophenotypic and molecular features

Abstract

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Keywords

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