Mortalità di una coorte di soggetti affetti da schizofrenia, disturbo bipolare, stato paranoide e altre psicosi non organiche ad un anno dal ricovero; confronto con la popolazione generale della Città di Torino

[Machine translation] Intro Recent studies have observed in people suffering from schizophrenia and bipolar disorder a mortality rate twice that of the general population both for all causes and for some specific causes, with a life expectancy of 10 to 25 years lower than that of healthy controls of the same age. This mortality differential is already observed in the first two years after hospital discharge. To explain this differential, both a major vulnerability of these individuals to risky behavior and lifestyle-related pathologies, both treatment with antipsychotic drugs and low socioeconomic status. Objectives The objective of the present study is to estimate in a cohort of people hospitalized for schizophrenia, bipolar disorder, paranoid state and other non-organic psychoses the risk of death for all causes and for some specific causes one year after discharge. Methods The study population consists of people living in Turin hospitalized between 1 January 1997 and 31 December 2007 for one of the psychiatric disorders considered (schizophrenia, bipolar disorder, paranoid state and other non-organic psychoses). To retrieve other information of interest, the identified SDOs were linked using an anonymous unique code to the Turin historical registry, the 2001 census and the mortality archive. It will be the trend in general mortality by year has been studied, while the specific mortality and by subgroups of psychiatric diagnosis will be studied over the entire period. The standardized mortality ratios (SMR) for the general population of Turin will be calculated. Results In the period 1997-2007, 26,593 dismissals (an average of 2,418 per year) were identified in the SDO archive for one of the psychiatric pathologies considered, carried out by 8,107 subjects including 47.3% male and 52.7% female, with an average age of 50.2 years (46.4 years in males and 53.6 years in females). Each subject was hospitalized an average of 3.3 times. Mortality analyses will be carried out on these subjects. Conclusions The results of this study will help to clarify whether patients suffering from schizophrenia, bipolar disorder, paranoid state and other non-organic psychoses have a higher mortality than the general population in Italy, and will highlight the possible need for specific interventions to reduce this differential.