Molecular pathways of odontogenic keratocysts: A systematic review

Objective: This systematic review aims to identify the molecular aspects of odontogenic keratocysts that have been elucidated to date. Methods: The odontogenic keratocyst (OKC) stands out as one of the most prevalent odontogenic tumors. Since its initial description, numerous studies have delved into various aspects of this lesion, aiming to unravel its distinctive biological behavior. Results: Recent investigations have speci cally focused on the molecular aspects of OKC, shedding light on its biological characteristics. Substantial differences at the molecular level between OKC and other odontogenic cystic lesions indicate a distinct biological origin. Genetic and molecular research in the realm of odontogenic tumors, particularly OKC, has contributed signi cantly to the growing knowledge and understanding of their physiopathological pathways. Conclusion: The molecular ndings may open non-surgical, pharmaceutical options for treatment.