Modified jatrophane diterpenes as modulators of multidrug resistance from Euphorbia dendroides L.

Gabriella Corea, Ernesto Fattorusso, Virginia Lanzotti, Orazio Taglialatela-Scafati, Giovanni Appendino, Mauro Ballero, Pierre Noël Simon, Charles Dumontet, Attilio Di Pietro

Research output: Contribution to journalArticlepeer-review

Abstract

The new diterpenoids terracinolides J-L (1-3), 13α-OH terracinolide F (8), abeodendroidin F (11) and epiabeodendroidin F (12) have been identified from Euphorbia dendroides L. The new compounds and six co-occurring known terracinolides were tested as inhibitors of the drug-efflux activity of P-glycoprotein from cancer cells. The results were used to extend the structure-activity relationships established for this class of compounds highlighting the relevance of substitution at positions 2, 3, 6, and 15 and disclosing a remarkable tolerance toward connectivity changes in the terpenoid core.

Original languageEnglish
Pages (from-to)5221-5227
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume11
Issue number23
DOIs
Publication statusPublished - 17 Nov 2003
Externally publishedYes

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