TY - JOUR
T1 - Moderate-to-severe atopic dermatitis in adolescents treated with dupilumab
T2 - A multicentre Italian real-world experience
AU - DADA – Dupilumab for Atopic Dermatitis of the Adolescence Study Group
AU - Stingeni, L.
AU - Bianchi, L.
AU - Antonelli, E.
AU - Caroppo, E. S.
AU - Ferrucci, S. M.
AU - Ortoncelli, M.
AU - Fabbrocini, G.
AU - Nettis, E.
AU - Schena, D.
AU - Napolitano, M.
AU - Gola, M.
AU - Bonzano, L.
AU - Rossi, M.
AU - Belloni Fortina, A.
AU - Balato, A.
AU - Peris, K.
AU - Foti, C.
AU - Guarneri, F.
AU - Romanelli, M.
AU - Patruno, C.
AU - Savoia, P.
AU - Fargnoli, M. C.
AU - Russo, F.
AU - Errichetti, E.
AU - Bianchelli, T.
AU - Bianchi, L.
AU - Pellacani, G.
AU - Feliciani, C.
AU - Offidani, A.
AU - Corazza, M.
AU - Micali, G.
AU - Milanesi, N.
AU - Malara, G.
AU - Chiricozzi, A.
AU - Tramontana, M.
AU - Hansel, K.
AU - Bini, Vittorio
AU - Buligan, Cinzia
AU - Caroppo, Francesca
AU - Dal Bello, Giacomo
AU - Dastoli, Stefano
AU - Di Brizzi, Eugenia Veronica
AU - De Felici Del Giudice, Maria Beatrice
AU - Diluvio, Laura
AU - Esposito, Maria
AU - Gelmetti, Alessandra
AU - Giacchetti, Alfredo
AU - Grieco, Teresa
AU - Iannone, Michela
AU - Macchia, Luigi
N1 - Publisher Copyright:
© 2022 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.
PY - 2022/8
Y1 - 2022/8
N2 - Background: Moderate-to-severe atopic dermatitis (AD) in the adolescence is a high burden disease, and its treatment can be very challenging due to paucity of approved systemic drugs for this age and their side-effects. Dupilumab was recently approved for treatment of adolescent AD. Objectives: A multicentre, prospective, real-world study on the effectiveness and safety of dupilumab in adolescents (aged from ≥12 to <18 years) with moderate-to-severe AD was conducted. The main AD clinical phenotypes were also examined. Methods: Data of adolescents with moderate-to-severe AD treated with dupilumab at label dosage for 16 weeks were collected. Treatment outcome was assessed by EASI, NRS itch, NRS sleep loss and CDLQI scores at baseline and after 16 weeks of treatment. The clinical scores were also evaluated according to clinical phenotypes. Results: One hundred and thirty-nine adolescents were enrolled in the study. Flexural eczema and head and neck eczema were the most frequent clinical phenotypes, followed by hand eczema and portrait-like dermatitis. Coexistence of more than 1 phenotype was documented in 126/139 (88.5%) adolescents. Three patients (2.1%) contracted asymptomatic SARS-CoV-2 infection and 1 of the discontinued dupilumab treatment before the target treatment period. A significant improvement in EASI, NRS itch, NRS sleep loss and CDLQI was observed after 16 weeks of treatment with dupilumab. This outcome was better than that observed in clinical trials. Dupilumab resulted effective in all AD phenotypes, especially in diffuse eczema. Twenty-eight (20.1%) patients reported adverse events, conjunctivitis and flushing being the most frequent. None of patients discontinued dupilumab due to adverse event. Conclusions: Dupilumab in adolescent AD showed excellent effectiveness at week 16 with consistent improvement of all clinical scores. Moreover, dupilumab showed a good safety profile also in this COVID-19 pandemic era.
AB - Background: Moderate-to-severe atopic dermatitis (AD) in the adolescence is a high burden disease, and its treatment can be very challenging due to paucity of approved systemic drugs for this age and their side-effects. Dupilumab was recently approved for treatment of adolescent AD. Objectives: A multicentre, prospective, real-world study on the effectiveness and safety of dupilumab in adolescents (aged from ≥12 to <18 years) with moderate-to-severe AD was conducted. The main AD clinical phenotypes were also examined. Methods: Data of adolescents with moderate-to-severe AD treated with dupilumab at label dosage for 16 weeks were collected. Treatment outcome was assessed by EASI, NRS itch, NRS sleep loss and CDLQI scores at baseline and after 16 weeks of treatment. The clinical scores were also evaluated according to clinical phenotypes. Results: One hundred and thirty-nine adolescents were enrolled in the study. Flexural eczema and head and neck eczema were the most frequent clinical phenotypes, followed by hand eczema and portrait-like dermatitis. Coexistence of more than 1 phenotype was documented in 126/139 (88.5%) adolescents. Three patients (2.1%) contracted asymptomatic SARS-CoV-2 infection and 1 of the discontinued dupilumab treatment before the target treatment period. A significant improvement in EASI, NRS itch, NRS sleep loss and CDLQI was observed after 16 weeks of treatment with dupilumab. This outcome was better than that observed in clinical trials. Dupilumab resulted effective in all AD phenotypes, especially in diffuse eczema. Twenty-eight (20.1%) patients reported adverse events, conjunctivitis and flushing being the most frequent. None of patients discontinued dupilumab due to adverse event. Conclusions: Dupilumab in adolescent AD showed excellent effectiveness at week 16 with consistent improvement of all clinical scores. Moreover, dupilumab showed a good safety profile also in this COVID-19 pandemic era.
UR - https://www.scopus.com/pages/publications/85133672183
U2 - 10.1111/jdv.18141
DO - 10.1111/jdv.18141
M3 - Article
SN - 0926-9959
VL - 36
SP - 1292
EP - 1299
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
IS - 8
ER -
SDG 3 Good Health and Well-being