TY - JOUR
T1 - Microenvironmental Interactions in Chronic Lymphocytic Leukemia
T2 - The Master Role of CD49d
AU - Dal Bo, Michele
AU - Tissino, Erika
AU - Benedetti, Dania
AU - Caldana, Chiara
AU - Bomben, Riccardo
AU - Del Poeta, Giovanni
AU - Gaidano, Gianluca
AU - Rossi, Francesca Maria
AU - Zucchetto, Antonella
AU - Gattei, Valter
N1 - Funding Information:
Funding: This research was supported in part by: the Associazione Italiana Ricerca Cancro (AIRC), Investigator Grant IG-13227, MFAG-10327; Progetto Ricerca Finalizzata I.R.C.C.S. n. RF-2009-1469205, n. RF-2010-2307262, Progetto Giovani Ricercatori n. GR-2009-1475467, Ministero della Salute, Rome, Italy; Fondazione Internazionale di Ricerca in Medicina Sperimentale (FIRMS) Turin, Italy; Associazione Italiana contro le Leucemie, linfomi e mielomi (AIL), Venezia Section, Pramaggiore Group, Italy; Ricerca Scientifica Applicata, Regione Friuli Venezia Giulia (“Linfonet” Project), Trieste, Italy; and the “5 × 1000 Intramural Program,” Centro di Riferimento Oncologico, Aviano, Italy.
PY - 2014/7
Y1 - 2014/7
N2 - Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation/expansion of a clonal population of neoplastic cells with the morphologic appearance of small mature B lymphocytes in blood, bone marrow, and lymphoid organs. A combination of genetic lesions is primarily responsible for the first step(s) of neoplastic transformation, along with microenvironmental signals, which concurrently operate by enhancing proliferation and/or inhibiting apoptosis. In this context, CD49d is known to play a pivotal role in mediating both cell-cell and cell-matrix interactions in CLL-involved tissues, eventually delivering pro-survival signals and protecting CLL cells from drug-induced damages. In the present review, we address, in detail, CD49d activities in the CLL microenvironment, CD49d functional and physical interactions with other microenvironmental receptors (including CD38 and B-cell receptor), and the relationship of CD49d expression with specific cytogenetic features in CLL.
AB - Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation/expansion of a clonal population of neoplastic cells with the morphologic appearance of small mature B lymphocytes in blood, bone marrow, and lymphoid organs. A combination of genetic lesions is primarily responsible for the first step(s) of neoplastic transformation, along with microenvironmental signals, which concurrently operate by enhancing proliferation and/or inhibiting apoptosis. In this context, CD49d is known to play a pivotal role in mediating both cell-cell and cell-matrix interactions in CLL-involved tissues, eventually delivering pro-survival signals and protecting CLL cells from drug-induced damages. In the present review, we address, in detail, CD49d activities in the CLL microenvironment, CD49d functional and physical interactions with other microenvironmental receptors (including CD38 and B-cell receptor), and the relationship of CD49d expression with specific cytogenetic features in CLL.
UR - https://www.scopus.com/pages/publications/84904429269
U2 - 10.1053/j.seminhematol.2014.05.002
DO - 10.1053/j.seminhematol.2014.05.002
M3 - Article
SN - 0037-1963
VL - 51
SP - 168
EP - 176
JO - Seminars in Hematology
JF - Seminars in Hematology
IS - 3
ER -