Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites

Keyphrases

• Metabolic Fate 100%
• Combretastatin A4 Phosphate (CA4P) 100%
• MS-MS 100%
• Biological Evaluation 100%
• Reactive Metabolites 100%
• LC-DAD-MS 100%
• Cytotoxicity 66%
• Tubulin 66%
• Quinones 66%
• Rat Liver Microsomes 33%
• Metabolism 33%
• In Vitro Metabolism 33%
• Human Liver Microsomes 33%
• Chemical Interaction 33%
• Trapping Agent 33%
• Covalent Bond 33%
• Sulphydryl Groups 33%
• Antineoplastic Agents 33%
• LC-MS Analysis 33%
• Phase I Trial 33%
• Urine Samples 33%
• Nucleophilic 33%
• Metabolic Study 33%
• Polymer Support 33%
• Ellman's Method 33%
• HPLC-UV-MS 33%
• Haptenation 33%
• Metabolic Pathways 33%
• Good Yields 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Combretastatin 100%
• Tubulin 66%
• Cytotoxicity 66%
• Rat 66%
• Clinical Trial 33%
• Oxidizing Agent 33%
• Anticarcinogen 33%
• Covalent Bond 33%
• Chemical Interaction 33%