Macrophage fusion cuisine

Antonio Sica; Alberto Mantovani

doi:10.1182/blood-2009-09-242800

Macrophage fusion cuisine

Antonio Sica
, Alberto Mantovani

Research output: Contribution to journal › Comment/debate

Abstract

In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.¹ This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.

Original language	English
Pages (from-to)	4609-4610
Number of pages	2
Journal	Blood
Volume	114
Issue number	21
DOIs	https://doi.org/10.1182/blood-2009-09-242800
Publication status	Published - 19 Nov 2009
Externally published	Yes

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10.1182/blood-2009-09-242800

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title = "Macrophage fusion cuisine",

abstract = "In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.1 This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.",

author = "Antonio Sica and Alberto Mantovani",

year = "2009",

month = nov,

day = "19",

doi = "10.1182/blood-2009-09-242800",

language = "English",

volume = "114",

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journal = "Blood",

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TY - JOUR

T1 - Macrophage fusion cuisine

AU - Sica, Antonio

AU - Mantovani, Alberto

PY - 2009/11/19

Y1 - 2009/11/19

N2 - In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.1 This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.

AB - In this issue of Blood, Van den Bossche and colleagues identify E-cadherin as a new IL-4/IL-4Rα/STAT6-induced and polyamine-dependent marker of M2 polarized macrophages.1 This new pathway promotes formation of the E-cadherin/β-catenin complex, leading to homotypic and heterotypic cellular fusion (see figure) and plays an important role in guiding macrophage functions associated with Th2 immune responses.

UR - https://www.scopus.com/pages/publications/77950397414

U2 - 10.1182/blood-2009-09-242800

DO - 10.1182/blood-2009-09-242800

M3 - Comment/debate

SN - 0006-4971

VL - 114

SP - 4609

EP - 4610

JO - Blood

JF - Blood

IS - 21

ER -

Macrophage fusion cuisine

Abstract

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