Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor

Filippo Renò; Manuela Rizzi; Marco Invernizzi; Mario Migliario; Carlo Cisari

doi:10.1016/j.ejphar.2013.08.044

Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor

Filippo Renò
, Manuela Rizzi
, Marco Invernizzi
, Mario Migliario
, Carlo Cisari

Research output: Contribution to journal › Article › peer-review

Abstract

Amino-bisphosphonates (N-BPs) have a wide range of clinical applications to treat bone diseases. Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase. In epithelial cells it has been demonstrated that FPP reduces both cell proliferation and migration activting glucocorticoid receptor. In this study two N-BPs (zoledronate and neridronate) used at low concentrations (100 nM to 10 μM) are able to stimulate human keratinocytes proliferation reducing glucocorticoid receptor activation.

Original language	English
Pages (from-to)	301-304
Number of pages	4
Journal	European Journal of Pharmacology
Volume	721
Issue number	1-3
DOIs	https://doi.org/10.1016/j.ejphar.2013.08.044
Publication status	Published - 5 Dec 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Amino-bisphosphonate
Glucocorticoid receptor
Human keratinocyte

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10.1016/j.ejphar.2013.08.044

Cite this

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title = "Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor",

abstract = "Amino-bisphosphonates (N-BPs) have a wide range of clinical applications to treat bone diseases. Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase. In epithelial cells it has been demonstrated that FPP reduces both cell proliferation and migration activting glucocorticoid receptor. In this study two N-BPs (zoledronate and neridronate) used at low concentrations (100 nM to 10 μM) are able to stimulate human keratinocytes proliferation reducing glucocorticoid receptor activation.",

keywords = "Amino-bisphosphonate, Glucocorticoid receptor, Human keratinocyte",

author = "Filippo Ren{\`o} and Manuela Rizzi and Marco Invernizzi and Mario Migliario and Carlo Cisari",

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doi = "10.1016/j.ejphar.2013.08.044",

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TY - JOUR

T1 - Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor

AU - Renò, Filippo

AU - Rizzi, Manuela

AU - Invernizzi, Marco

AU - Migliario, Mario

AU - Cisari, Carlo

PY - 2013/12/5

Y1 - 2013/12/5

N2 - Amino-bisphosphonates (N-BPs) have a wide range of clinical applications to treat bone diseases. Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase. In epithelial cells it has been demonstrated that FPP reduces both cell proliferation and migration activting glucocorticoid receptor. In this study two N-BPs (zoledronate and neridronate) used at low concentrations (100 nM to 10 μM) are able to stimulate human keratinocytes proliferation reducing glucocorticoid receptor activation.

AB - Amino-bisphosphonates (N-BPs) have a wide range of clinical applications to treat bone diseases. Their activity lowered farnesyl pyrophosphate (FPP) endogenous levels by inhibiting FPP synthase. In epithelial cells it has been demonstrated that FPP reduces both cell proliferation and migration activting glucocorticoid receptor. In this study two N-BPs (zoledronate and neridronate) used at low concentrations (100 nM to 10 μM) are able to stimulate human keratinocytes proliferation reducing glucocorticoid receptor activation.

KW - Amino-bisphosphonate

KW - Glucocorticoid receptor

KW - Human keratinocyte

UR - https://www.scopus.com/pages/publications/84890128485

U2 - 10.1016/j.ejphar.2013.08.044

DO - 10.1016/j.ejphar.2013.08.044

M3 - Article

SN - 0014-2999

VL - 721

SP - 301

EP - 304

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1-3

ER -

Low doses amino-bisphosphonates stimulate keratinocytes growth inactivating glucocorticoid receptor

Abstract

UN SDGs

Keywords

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