Long-term Prognostic Impact of Chromosome Abnormalities in Clear Cell Renal Cell Carcinoma

CARLOTTA PALUMBO, M. Furlan, P. Balzarini, T. Zanotelli, A. Cozzoli, A. Veccia, S. Francavilla, S. Zamboni, R. Tardanico, C. Simeone, A. Antonelli

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: Clear cell renal cell carcinoma (ccRCC) shows variable chromosomal abnormalities. The aim of this study was to assess the prognostic role of ccRCC chromosomal abnormalities in a single-center cohort with an extended follow-up. Materials and Methods: A systematic cytogenetic analysis was performed in 283 consecutive surgically-treated patients for renal masses between 1997 and 2002. Kaplan–Meier and multivariable Cox regression (MCR) models were used to calculate cancer specific survival (CSS). Results: Among 174 ccRCC patients, the most common abnormality was deletion in chromosome 3 (54.6%). At a median follow-up of 119 months, 38 patients (21.8%) died from RCC. At MCR models, worse CSS was independently predicted by deletions in chromosomes 2, 19, 20 or 22 and insertions in chromosome 18. Conclusion: Specific ccRCC chromosomal abnormalities are independently associated with worse CSS. Cytogenetic evaluation may direct further genetic analysis for personalized prognostic stratification.
Original languageEnglish
Pages (from-to)2757-2765
Number of pages9
JournalAnticancer Research
Volume39
Issue number6
DOIs
Publication statusPublished - 2019

Keywords

  • Chromosome imbalance
  • Clear cell
  • Karyotype
  • Prognosis
  • Renal cell carcinoma
  • Survival

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