Long-acting delivery systems for peptides: reduced plasma testosterone levels in male rats after a single injection

M. R. Gasco; F. Pattarino; F. Lattanzi

doi:10.1016/0378-5173(90)90225-S

Long-acting delivery systems for peptides: reduced plasma testosterone levels in male rats after a single injection

M. R. Gasco, F. Pattarino, F. Lattanzi

Research output: Contribution to journal › Article › peer-review

Abstract

The study of a biocompatible w/o microemulsion for parenteral administration of peptides was performed. The behaviour of an LH-RH analog, [d-Trp-6]LH-RH, in a w/o microemulsion was evaluated both in vitro and in vivo. After a single intramuscular injection in rats of the microemulsion containing 500 μg/ml of the drug, the plasma levels of testosterone fell; between 10 and 20 days after injection, the plasma testosterone level was lower than that observed after daily injections of 100 μg/kg of the LH-RH analog. The results suggested that prolonged action and protection of biodegradable molecules could be achieved by using w/o microemulsions administered parenterally.

Original language	English
Pages (from-to)	119-123
Number of pages	5
Journal	International Journal of Pharmaceutics
Volume	62
Issue number	2-3
DOIs	https://doi.org/10.1016/0378-5173(90)90225-S
Publication status	Published - 31 Jul 1990
Externally published	Yes

Keywords

Hormone analog
LH-RH
Long-acting delivery
Microemulsion, w/o

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10.1016/0378-5173(90)90225-S

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title = "Long-acting delivery systems for peptides: reduced plasma testosterone levels in male rats after a single injection",

abstract = "The study of a biocompatible w/o microemulsion for parenteral administration of peptides was performed. The behaviour of an LH-RH analog, [d-Trp-6]LH-RH, in a w/o microemulsion was evaluated both in vitro and in vivo. After a single intramuscular injection in rats of the microemulsion containing 500 μg/ml of the drug, the plasma levels of testosterone fell; between 10 and 20 days after injection, the plasma testosterone level was lower than that observed after daily injections of 100 μg/kg of the LH-RH analog. The results suggested that prolonged action and protection of biodegradable molecules could be achieved by using w/o microemulsions administered parenterally.",

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doi = "10.1016/0378-5173(90)90225-S",

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T1 - Long-acting delivery systems for peptides

T2 - reduced plasma testosterone levels in male rats after a single injection

AU - Gasco, M. R.

AU - Pattarino, F.

AU - Lattanzi, F.

PY - 1990/7/31

Y1 - 1990/7/31

N2 - The study of a biocompatible w/o microemulsion for parenteral administration of peptides was performed. The behaviour of an LH-RH analog, [d-Trp-6]LH-RH, in a w/o microemulsion was evaluated both in vitro and in vivo. After a single intramuscular injection in rats of the microemulsion containing 500 μg/ml of the drug, the plasma levels of testosterone fell; between 10 and 20 days after injection, the plasma testosterone level was lower than that observed after daily injections of 100 μg/kg of the LH-RH analog. The results suggested that prolonged action and protection of biodegradable molecules could be achieved by using w/o microemulsions administered parenterally.

AB - The study of a biocompatible w/o microemulsion for parenteral administration of peptides was performed. The behaviour of an LH-RH analog, [d-Trp-6]LH-RH, in a w/o microemulsion was evaluated both in vitro and in vivo. After a single intramuscular injection in rats of the microemulsion containing 500 μg/ml of the drug, the plasma levels of testosterone fell; between 10 and 20 days after injection, the plasma testosterone level was lower than that observed after daily injections of 100 μg/kg of the LH-RH analog. The results suggested that prolonged action and protection of biodegradable molecules could be achieved by using w/o microemulsions administered parenterally.

KW - Hormone analog

KW - LH-RH

KW - Long-acting delivery

KW - Microemulsion, w/o

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DO - 10.1016/0378-5173(90)90225-S

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VL - 62

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EP - 123

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 2-3

ER -

Long-acting delivery systems for peptides: reduced plasma testosterone levels in male rats after a single injection

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Keywords

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