Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles

Giuseppe Ferrauto, Fabio Carniato, Enza Di Gregorio, Lorenzo Tei, Mauro Botta, Silvio Aime

Research output: Contribution to journalArticlepeer-review

Abstract

Indocyanine green was encapsulated inside the pores of pegylated amino-functionalized MCM-41 Mesoporous Silica Nanoparticles (ICG-MSNs). In addition to a greater stability and a decrease of toxicity, the photoacoustic effect of ICG-MSNs increases by nearly 400% compared to free ICG due to fluorescence quenching and high photothermal conversion of the encapsulated dyes. Upon i.v. administration in tumor-bearing mice, an overall photoacoustic enhancement of ca. 25% was measured in the tumor region.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalNanoscale
Volume9
Issue number1
DOIs
Publication statusPublished - 7 Jan 2017

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