Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii

W. He; M. Cik; A. Lesage; I. van der Linden; N. De Kimpe; G. Appendino; J. Bracke; S. G. Mathenge; F. P. Mudida; J. E. Leysen; L. van Puyvelde

doi:10.1021/np000249u

Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii

W. He
, M. Cik
, A. Lesage
, I. van der Linden
, N. De Kimpe
, G. Appendino
, J. Bracke
, S. G. Mathenge
, F. P. Mudida
, J. E. Leysen
, L. van Puyvelde

Research output: Contribution to journal › Article › peer-review

Abstract

The bioassay-guided fractionation of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as a powerful neurotrophic constituent.

Original language	English
Pages (from-to)	1185-1187
Number of pages	3
Journal	Journal of Natural Products
Volume	63
Issue number	9
DOIs	https://doi.org/10.1021/np000249u
Publication status	Published - 2000
Externally published	Yes

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10.1021/np000249u

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title = "Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii",

abstract = "The bioassay-guided fractionation of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as a powerful neurotrophic constituent.",

author = "W. He and M. Cik and A. Lesage and \{van der Linden\}, I. and \{De Kimpe\}, N. and G. Appendino and J. Bracke and Mathenge, \{S. G.\} and Mudida, \{F. P.\} and Leysen, \{J. E.\} and \{van Puyvelde\}, L.",

year = "2000",

doi = "10.1021/np000249u",

language = "English",

volume = "63",

pages = "1185--1187",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "9",

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TY - JOUR

T1 - Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii

AU - He, W.

AU - Cik, M.

AU - Lesage, A.

AU - van der Linden, I.

AU - De Kimpe, N.

AU - Appendino, G.

AU - Bracke, J.

AU - Mathenge, S. G.

AU - Mudida, F. P.

AU - Leysen, J. E.

AU - van Puyvelde, L.

PY - 2000

Y1 - 2000

N2 - The bioassay-guided fractionation of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as a powerful neurotrophic constituent.

AB - The bioassay-guided fractionation of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as a powerful neurotrophic constituent.

UR - https://www.scopus.com/pages/publications/0033797418

U2 - 10.1021/np000249u

DO - 10.1021/np000249u

M3 - Article

SN - 0163-3864

VL - 63

SP - 1185

EP - 1187

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii

Abstract

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