Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii

W. He; M. Cik; A. Lesage; I. van der Linden; N. De Kimpe; G. Appendino; J. Bracke; S. G. Mathenge; F. P. Mudida; J. E. Leysen; L. van Puyvelde

doi:10.1021/np000249u

Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii

W. He, M. Cik, A. Lesage, I. van der Linden, N. De Kimpe, G. Appendino, J. Bracke, S. G. Mathenge, F. P. Mudida, J. E. Leysen, L. van Puyvelde

Research output: Contribution to journal › Article › peer-review

Abstract

The bioassay-guided fractionation of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as a powerful neurotrophic constituent.

Original language	English
Pages (from-to)	1185-1187
Number of pages	3
Journal	Journal of Natural Products
Volume	63
Issue number	9
DOIs	https://doi.org/10.1021/np000249u
Publication status	Published - 2000
Externally published	Yes

Access to Document

10.1021/np000249u

Cite this

@article{4b2dc3313c5a4698a524c2ec03b88676,

title = "Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii",

abstract = "The bioassay-guided fractionation of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as a powerful neurotrophic constituent.",

author = "W. He and M. Cik and A. Lesage and {van der Linden}, I. and {De Kimpe}, N. and G. Appendino and J. Bracke and Mathenge, {S. G.} and Mudida, {F. P.} and Leysen, {J. E.} and {van Puyvelde}, L.",

year = "2000",

doi = "10.1021/np000249u",

language = "English",

volume = "63",

pages = "1185--1187",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "9",

}

TY - JOUR

T1 - Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii

AU - He, W.

AU - Cik, M.

AU - Lesage, A.

AU - van der Linden, I.

AU - De Kimpe, N.

AU - Appendino, G.

AU - Bracke, J.

AU - Mathenge, S. G.

AU - Mudida, F. P.

AU - Leysen, J. E.

AU - van Puyvelde, L.

PY - 2000

Y1 - 2000

N2 - The bioassay-guided fractionation of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as a powerful neurotrophic constituent.

AB - The bioassay-guided fractionation of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as a powerful neurotrophic constituent.

UR - http://www.scopus.com/inward/record.url?scp=0033797418&partnerID=8YFLogxK

U2 - 10.1021/np000249u

DO - 10.1021/np000249u

M3 - Article

SN - 0163-3864

VL - 63

SP - 1185

EP - 1187

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii

Abstract

Access to Document

Other files and links

Fingerprint

Cite this