TY - JOUR
T1 - Intraoperative individualization of positive-end-expiratory pressure through electrical impedance tomography or esophageal pressure assessment: a systematic review and meta-analysis of randomized controlled trials
AU - Esposito, Teresa
AU - Fregonese, Martina
AU - Morettini, Giulio
AU - Carboni, Paloma
AU - Tardioli, Cecilia
AU - Messina, Antonio
AU - VASCHETTO, Rosanna
AU - Della Corte, Francesco
AU - Vetrugno, Luigi
AU - Navalesi, Paolo
AU - De Robertis, Edoardo
AU - Azzolina, Danila
AU - Piriyapatsom, Annop
AU - Tucci, Mauro R
AU - Wrigge, Hermann
AU - Simon, Philipp
AU - Bignami, Elena
AU - Maggiore, Salvatore M
AU - Simonte, Rachele
AU - CAMMAROTA, Gianmaria
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature B.V. 2023.
PY - 2023
Y1 - 2023
N2 - Purpose: This systematic review of randomized-controlled trials (RCTs) with meta-analyses aimed to compare the effects on intraoperative arterial oxygen tension to inspired oxygen fraction ratio (PaO2/FiO2), exerted by positive end-expiratory pressure (PEEP) individualized trough electrical impedance tomography (EIT) or esophageal pressure (Pes) assessment (intervention) vs. PEEP not tailored on EIT or Pes (control), in patients undergoing abdominal or pelvic surgery with an open or laparoscopic/robotic approach. Methods: PUBMED®, EMBASE®, and Cochrane Controlled Clinical trials register were searched for observational studies and RCTs from inception to the end of August 2022. Inclusion criteria were: RCTs comparing PEEP titrated on EIT/Pes assessment vs. PEEP not individualized on EIT/Pes and reporting intraoperative PaO2/FiO2. Two authors independently extracted data from the enrolled investigations. Data are reported as mean difference and 95% confidence interval (CI). Results: Six RCTs were included for a total of 240 patients undergoing general anesthesia for surgery, of whom 117 subjects in the intervention group and 123 subjects in the control group. The intraoperative mean PaO2/FiO2 was 69.6 (95%CI 32.-106.4 ) mmHg higher in the intervention group as compared with the control group with 81.4% between-study heterogeneity (p < 0.01). However, at meta-regression, the between-study heterogeneity diminished to 44.96% when data were moderated for body mass index (estimate 3.45, 95%CI 0.78-6.11, p = 0.011). Conclusions: In patients undergoing abdominal or pelvic surgery with an open or laparoscopic/robotic approach, PEEP personalized by EIT or Pes allowed the achievement of a better intraoperative oxygenation compared to PEEP not individualized through EIT or Pes. Prospero registration number: CRD 42021218306, 30/01/2023.
AB - Purpose: This systematic review of randomized-controlled trials (RCTs) with meta-analyses aimed to compare the effects on intraoperative arterial oxygen tension to inspired oxygen fraction ratio (PaO2/FiO2), exerted by positive end-expiratory pressure (PEEP) individualized trough electrical impedance tomography (EIT) or esophageal pressure (Pes) assessment (intervention) vs. PEEP not tailored on EIT or Pes (control), in patients undergoing abdominal or pelvic surgery with an open or laparoscopic/robotic approach. Methods: PUBMED®, EMBASE®, and Cochrane Controlled Clinical trials register were searched for observational studies and RCTs from inception to the end of August 2022. Inclusion criteria were: RCTs comparing PEEP titrated on EIT/Pes assessment vs. PEEP not individualized on EIT/Pes and reporting intraoperative PaO2/FiO2. Two authors independently extracted data from the enrolled investigations. Data are reported as mean difference and 95% confidence interval (CI). Results: Six RCTs were included for a total of 240 patients undergoing general anesthesia for surgery, of whom 117 subjects in the intervention group and 123 subjects in the control group. The intraoperative mean PaO2/FiO2 was 69.6 (95%CI 32.-106.4 ) mmHg higher in the intervention group as compared with the control group with 81.4% between-study heterogeneity (p < 0.01). However, at meta-regression, the between-study heterogeneity diminished to 44.96% when data were moderated for body mass index (estimate 3.45, 95%CI 0.78-6.11, p = 0.011). Conclusions: In patients undergoing abdominal or pelvic surgery with an open or laparoscopic/robotic approach, PEEP personalized by EIT or Pes allowed the achievement of a better intraoperative oxygenation compared to PEEP not individualized through EIT or Pes. Prospero registration number: CRD 42021218306, 30/01/2023.
KW - Electrical impedance tomography
KW - Esophageal pressure
KW - Intraoperative mechanical ventilation
KW - Intraoperative oxygenation
KW - Pulmonary complications
KW - Electrical impedance tomography
KW - Esophageal pressure
KW - Intraoperative mechanical ventilation
KW - Intraoperative oxygenation
KW - Pulmonary complications
UR - https://iris.uniupo.it/handle/11579/165782
U2 - 10.1007/s10877-023-01094-2
DO - 10.1007/s10877-023-01094-2
M3 - Article
SN - 1387-1307
JO - Journal of Clinical Monitoring and Computing
JF - Journal of Clinical Monitoring and Computing
ER -