Interleukin-6, tumor necrosis factor and corticosterone induction by central lipopolysaccharide in aged rats

Salvatore Terrazzino; Carlo Perego; Ada De Luigi; Maria Grazia De Simoni

doi:10.1016/S0024-3205(97)00534-1

Interleukin-6, tumor necrosis factor and corticosterone induction by central lipopolysaccharide in aged rats

Salvatore Terrazzino
, Carlo Perego
, Ada De Luigi
, Maria Grazia De Simoni

Research output: Contribution to journal › Article › peer-review

Abstract

Age-related changes of the immune-adrenal axis were studied in rats treated intracerebroventricularly with lipopolysaccharide (LPS, 2.5 μg/5μl) Serum interleukin-6 (IL-6), tumor necrosis factor (TNF) and corticosterone levels were evaluated in young (3 months) and old (24 months) Sprague-Dawley rats at different time-points. Old rats showed higher IL-6 levels compared to young rats while no change was observed on TNF levels in the two age groups. Corticosterone increase induced by LPS was lower in old than in young rats. The results show that heterogeneous modifications of the immune-adrenal axis occur that could have a pathophysiological role in the altered response to brain infections during aging.

Original language	English
Pages (from-to)	695-701
Number of pages	7
Journal	Life Sciences
Volume	61
Issue number	7
DOIs	https://doi.org/10.1016/S0024-3205(97)00534-1
Publication status	Published - 11 Jul 1997
Externally published	Yes

Keywords

Aging
Corticosterone
Interleukin-6
Lipopolysaccharide
Sprague-Dawley rats
Tumor necrosis factor

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10.1016/S0024-3205(97)00534-1

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@article{30cb2d7b2f8d4ba087318040acd657b2,

title = "Interleukin-6, tumor necrosis factor and corticosterone induction by central lipopolysaccharide in aged rats",

abstract = "Age-related changes of the immune-adrenal axis were studied in rats treated intracerebroventricularly with lipopolysaccharide (LPS, 2.5 μg/5μl) Serum interleukin-6 (IL-6), tumor necrosis factor (TNF) and corticosterone levels were evaluated in young (3 months) and old (24 months) Sprague-Dawley rats at different time-points. Old rats showed higher IL-6 levels compared to young rats while no change was observed on TNF levels in the two age groups. Corticosterone increase induced by LPS was lower in old than in young rats. The results show that heterogeneous modifications of the immune-adrenal axis occur that could have a pathophysiological role in the altered response to brain infections during aging.",

keywords = "Aging, Corticosterone, Interleukin-6, Lipopolysaccharide, Sprague-Dawley rats, Tumor necrosis factor",

author = "Salvatore Terrazzino and Carlo Perego and \{De Luigi\}, Ada and \{De Simoni\}, \{Maria Grazia\}",

note = "Funding Information: The work was partially supported by National Research Council, Targeted project {"}Prevention and Control Disease Factors{"}, subproject {"}Causes of Infectious Diseases{"}, contract No. 94.00693.PF41 and by Consiglio Nazionale delle Ricerche, Rome, Italy, Convenzione Psicofannacologia.",

year = "1997",

month = jul,

day = "11",

doi = "10.1016/S0024-3205(97)00534-1",

language = "English",

volume = "61",

pages = "695--701",

journal = "Life Sciences",

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TY - JOUR

T1 - Interleukin-6, tumor necrosis factor and corticosterone induction by central lipopolysaccharide in aged rats

AU - Terrazzino, Salvatore

AU - Perego, Carlo

AU - De Luigi, Ada

AU - De Simoni, Maria Grazia

N1 - Funding Information: The work was partially supported by National Research Council, Targeted project "Prevention and Control Disease Factors", subproject "Causes of Infectious Diseases", contract No. 94.00693.PF41 and by Consiglio Nazionale delle Ricerche, Rome, Italy, Convenzione Psicofannacologia.

PY - 1997/7/11

Y1 - 1997/7/11

N2 - Age-related changes of the immune-adrenal axis were studied in rats treated intracerebroventricularly with lipopolysaccharide (LPS, 2.5 μg/5μl) Serum interleukin-6 (IL-6), tumor necrosis factor (TNF) and corticosterone levels were evaluated in young (3 months) and old (24 months) Sprague-Dawley rats at different time-points. Old rats showed higher IL-6 levels compared to young rats while no change was observed on TNF levels in the two age groups. Corticosterone increase induced by LPS was lower in old than in young rats. The results show that heterogeneous modifications of the immune-adrenal axis occur that could have a pathophysiological role in the altered response to brain infections during aging.

AB - Age-related changes of the immune-adrenal axis were studied in rats treated intracerebroventricularly with lipopolysaccharide (LPS, 2.5 μg/5μl) Serum interleukin-6 (IL-6), tumor necrosis factor (TNF) and corticosterone levels were evaluated in young (3 months) and old (24 months) Sprague-Dawley rats at different time-points. Old rats showed higher IL-6 levels compared to young rats while no change was observed on TNF levels in the two age groups. Corticosterone increase induced by LPS was lower in old than in young rats. The results show that heterogeneous modifications of the immune-adrenal axis occur that could have a pathophysiological role in the altered response to brain infections during aging.

KW - Aging

KW - Corticosterone

KW - Interleukin-6

KW - Lipopolysaccharide

KW - Sprague-Dawley rats

KW - Tumor necrosis factor

UR - https://www.scopus.com/pages/publications/0030787289

U2 - 10.1016/S0024-3205(97)00534-1

DO - 10.1016/S0024-3205(97)00534-1

M3 - Article

SN - 0024-3205

VL - 61

SP - 695

EP - 701

JO - Life Sciences

JF - Life Sciences

IS - 7

ER -

Interleukin-6, tumor necrosis factor and corticosterone induction by central lipopolysaccharide in aged rats

Abstract

Keywords

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