Interleukin-6 gene expression and production induced in human monocytes by membrane proteoglycans from Klebsiella pneumoniae

Marina Sironi; Antonio Sica; Franca Riganti; Luciano Licciardello; Francesco Colotta; Alberto Mantovani

doi:10.1016/0192-0561(90)90021-E

Interleukin-6 gene expression and production induced in human monocytes by membrane proteoglycans from Klebsiella pneumoniae

Marina Sironi, Antonio Sica, Franca Riganti, Luciano Licciardello, Francesco Colotta, Alberto Mantovani

Research output: Contribution to journal › Article › peer-review

Abstract

The present study was designed to investigate the effect of membrane proteoglycans (MPG) from Klebsiella pneumoniae on IL-6 production by human peripheral blood monocytes. Exposure in vitro to MPG induced release of IL-6 activity from human monocytes, as assessed by the 7TD1 hybridoma assay. MPG-induced hybridoma growth factor activity was blocked by anti-IL-6 antibodies. MPG induced expression in human monocytes of IL-6 mRNA transcripts as assessed by Northern blot analysis. Induction of IL-6 in mononuclear phagocytes may play a role in the immunomodulatory activity of MPG.

Original language	English
Pages (from-to)	397-402
Number of pages	6
Journal	International Journal of Immunopharmacology
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/0192-0561(90)90021-E
Publication status	Published - 1990
Externally published	Yes

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10.1016/0192-0561(90)90021-E

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title = "Interleukin-6 gene expression and production induced in human monocytes by membrane proteoglycans from Klebsiella pneumoniae",

abstract = "The present study was designed to investigate the effect of membrane proteoglycans (MPG) from Klebsiella pneumoniae on IL-6 production by human peripheral blood monocytes. Exposure in vitro to MPG induced release of IL-6 activity from human monocytes, as assessed by the 7TD1 hybridoma assay. MPG-induced hybridoma growth factor activity was blocked by anti-IL-6 antibodies. MPG induced expression in human monocytes of IL-6 mRNA transcripts as assessed by Northern blot analysis. Induction of IL-6 in mononuclear phagocytes may play a role in the immunomodulatory activity of MPG.",

author = "Marina Sironi and Antonio Sica and Franca Riganti and Luciano Licciardello and Francesco Colotta and Alberto Mantovani",

year = "1990",

doi = "10.1016/0192-0561(90)90021-E",

language = "English",

volume = "12",

pages = "397--402",

journal = "International Journal of Immunopharmacology",

issn = "0192-0561",

publisher = "Elsevier B.V.",

number = "4",

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T1 - Interleukin-6 gene expression and production induced in human monocytes by membrane proteoglycans from Klebsiella pneumoniae

AU - Sironi, Marina

AU - Sica, Antonio

AU - Riganti, Franca

AU - Licciardello, Luciano

AU - Colotta, Francesco

AU - Mantovani, Alberto

PY - 1990

Y1 - 1990

N2 - The present study was designed to investigate the effect of membrane proteoglycans (MPG) from Klebsiella pneumoniae on IL-6 production by human peripheral blood monocytes. Exposure in vitro to MPG induced release of IL-6 activity from human monocytes, as assessed by the 7TD1 hybridoma assay. MPG-induced hybridoma growth factor activity was blocked by anti-IL-6 antibodies. MPG induced expression in human monocytes of IL-6 mRNA transcripts as assessed by Northern blot analysis. Induction of IL-6 in mononuclear phagocytes may play a role in the immunomodulatory activity of MPG.

AB - The present study was designed to investigate the effect of membrane proteoglycans (MPG) from Klebsiella pneumoniae on IL-6 production by human peripheral blood monocytes. Exposure in vitro to MPG induced release of IL-6 activity from human monocytes, as assessed by the 7TD1 hybridoma assay. MPG-induced hybridoma growth factor activity was blocked by anti-IL-6 antibodies. MPG induced expression in human monocytes of IL-6 mRNA transcripts as assessed by Northern blot analysis. Induction of IL-6 in mononuclear phagocytes may play a role in the immunomodulatory activity of MPG.

UR - http://www.scopus.com/inward/record.url?scp=0025373203&partnerID=8YFLogxK

U2 - 10.1016/0192-0561(90)90021-E

DO - 10.1016/0192-0561(90)90021-E

M3 - Article

SN - 0192-0561

VL - 12

SP - 397

EP - 402

JO - International Journal of Immunopharmacology

JF - International Journal of Immunopharmacology

IS - 4

ER -

Interleukin-6 gene expression and production induced in human monocytes by membrane proteoglycans from Klebsiella pneumoniae

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