Interleukin 3-dependent Proliferation of the Human MO-7e Cell Line Is Supported by Discrete Activation of Late d Genes

Gian Carlo Avanzi; Pierluigi Porcu; Maria Felice Brizzi; Luigi Pegoraro; Dario Ghigo; Amalia Bosia

Interleukin 3-dependent Proliferation of the Human MO-7e Cell Line Is Supported by Discrete Activation of Late d Genes

Gian Carlo Avanzi, Pierluigi Porcu, Maria Felice Brizzi, Luigi Pegoraro, Dario Ghigo, Amalia Bosia

Research output: Contribution to journal › Article › peer-review

Abstract

The hemopoietic growth factor interleukin 3 (IL-3) supports the survival and proliferation of multipotent and committed progenitor cells in vitro. To elucidate the molecular mechanisms triggered by IL-3 we studied the expression of cell cycle-related genes in a recently established human IL-3-de pendent clone (M-07e). No changes in the level of expression of early (c-myc), mid (ornithine decarboxylase), or mid-late Gi (p53, c-myb) cell cycle genes were detected after restoration of IL-3 in deprived cells. The fact that only late Gi-S-phase genes [proliferating cell nuclear antigen (PCNA) thymidine kinase (TK), histone H3] are modulated by IL-3 suggests that this factor may control human cell proliferation by acting at the d-S boundary.

Original language	English
Pages (from-to)	1741-1743
Number of pages	3
Journal	Cancer Research
Volume	51
Issue number	6
Publication status	Published - Mar 1991
Externally published	Yes

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title = "Interleukin 3-dependent Proliferation of the Human MO-7e Cell Line Is Supported by Discrete Activation of Late d Genes",

abstract = "The hemopoietic growth factor interleukin 3 (IL-3) supports the survival and proliferation of multipotent and committed progenitor cells in vitro. To elucidate the molecular mechanisms triggered by IL-3 we studied the expression of cell cycle-related genes in a recently established human IL-3-de pendent clone (M-07e). No changes in the level of expression of early (c-myc), mid (ornithine decarboxylase), or mid-late Gi (p53, c-myb) cell cycle genes were detected after restoration of IL-3 in deprived cells. The fact that only late Gi-S-phase genes [proliferating cell nuclear antigen (PCNA) thymidine kinase (TK), histone H3] are modulated by IL-3 suggests that this factor may control human cell proliferation by acting at the d-S boundary.",

author = "{Carlo Avanzi}, Gian and Pierluigi Porcu and {Felice Brizzi}, Maria and Luigi Pegoraro and Dario Ghigo and Amalia Bosia",

year = "1991",

month = mar,

language = "English",

volume = "51",

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T1 - Interleukin 3-dependent Proliferation of the Human MO-7e Cell Line Is Supported by Discrete Activation of Late d Genes

AU - Carlo Avanzi, Gian

AU - Porcu, Pierluigi

AU - Felice Brizzi, Maria

AU - Pegoraro, Luigi

AU - Ghigo, Dario

AU - Bosia, Amalia

PY - 1991/3

Y1 - 1991/3

N2 - The hemopoietic growth factor interleukin 3 (IL-3) supports the survival and proliferation of multipotent and committed progenitor cells in vitro. To elucidate the molecular mechanisms triggered by IL-3 we studied the expression of cell cycle-related genes in a recently established human IL-3-de pendent clone (M-07e). No changes in the level of expression of early (c-myc), mid (ornithine decarboxylase), or mid-late Gi (p53, c-myb) cell cycle genes were detected after restoration of IL-3 in deprived cells. The fact that only late Gi-S-phase genes [proliferating cell nuclear antigen (PCNA) thymidine kinase (TK), histone H3] are modulated by IL-3 suggests that this factor may control human cell proliferation by acting at the d-S boundary.

AB - The hemopoietic growth factor interleukin 3 (IL-3) supports the survival and proliferation of multipotent and committed progenitor cells in vitro. To elucidate the molecular mechanisms triggered by IL-3 we studied the expression of cell cycle-related genes in a recently established human IL-3-de pendent clone (M-07e). No changes in the level of expression of early (c-myc), mid (ornithine decarboxylase), or mid-late Gi (p53, c-myb) cell cycle genes were detected after restoration of IL-3 in deprived cells. The fact that only late Gi-S-phase genes [proliferating cell nuclear antigen (PCNA) thymidine kinase (TK), histone H3] are modulated by IL-3 suggests that this factor may control human cell proliferation by acting at the d-S boundary.

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M3 - Article

SN - 0008-5472

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Interleukin 3-dependent Proliferation of the Human MO-7e Cell Line Is Supported by Discrete Activation of Late d Genes

Abstract

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