Interferon-γ plays a crucial role in T lymphocyte reaction against alloantigens

Santo Landolfo; Franca Cofano; Mirella Giovarelli; Maria Prat; Giorgio Cavallo; Guido Forni

doi:10.1007/BF03029144

Interferon-γ plays a crucial role in T lymphocyte reaction against alloantigens

Santo Landolfo
, Franca Cofano
, Mirella Giovarelli
, Maria Prat
, Giorgio Cavallo
, Guido Forni

Research output: Contribution to journal › Article › peer-review

Abstract

In this study we report that addition to mixed lymphocyte reactions of monoclonal antibodies to interferon-γ inhibits alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity is not confined to in vitro models, since daily local injection of these antibodies in CBA/J mice blocks the rejection of fully allogeneic tumor cells consistently displayed by untreated CBA/J mcie.

Original language	English
Pages (from-to)	307-314
Number of pages	8
Journal	Ricerca in Clinica e in Laboratorio
Volume	15
Issue number	4
DOIs	https://doi.org/10.1007/BF03029144
Publication status	Published - Oct 1985
Externally published	Yes

Keywords

Allograft rejection
Mixed lymphocyte reaction
Monoclonal antibodies
Murine interferon-γ
T lymphocytes
Tumors

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10.1007/BF03029144

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abstract = "In this study we report that addition to mixed lymphocyte reactions of monoclonal antibodies to interferon-γ inhibits alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity is not confined to in vitro models, since daily local injection of these antibodies in CBA/J mice blocks the rejection of fully allogeneic tumor cells consistently displayed by untreated CBA/J mcie.",

keywords = "Allograft rejection, Mixed lymphocyte reaction, Monoclonal antibodies, Murine interferon-γ, T lymphocytes, Tumors",

author = "Santo Landolfo and Franca Cofano and Mirella Giovarelli and Maria Prat and Giorgio Cavallo and Guido Forni",

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AU - Landolfo, Santo

AU - Cofano, Franca

AU - Giovarelli, Mirella

AU - Prat, Maria

AU - Cavallo, Giorgio

AU - Forni, Guido

PY - 1985/10

Y1 - 1985/10

N2 - In this study we report that addition to mixed lymphocyte reactions of monoclonal antibodies to interferon-γ inhibits alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity is not confined to in vitro models, since daily local injection of these antibodies in CBA/J mice blocks the rejection of fully allogeneic tumor cells consistently displayed by untreated CBA/J mcie.

AB - In this study we report that addition to mixed lymphocyte reactions of monoclonal antibodies to interferon-γ inhibits alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity is not confined to in vitro models, since daily local injection of these antibodies in CBA/J mice blocks the rejection of fully allogeneic tumor cells consistently displayed by untreated CBA/J mcie.

KW - Allograft rejection

KW - Mixed lymphocyte reaction

KW - Monoclonal antibodies

KW - Murine interferon-γ

KW - T lymphocytes

KW - Tumors

UR - https://www.scopus.com/pages/publications/0022143457

U2 - 10.1007/BF03029144

DO - 10.1007/BF03029144

M3 - Article

SN - 0390-5748

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SP - 307

EP - 314

JO - Ricerca in Clinica e in Laboratorio

JF - Ricerca in Clinica e in Laboratorio

IS - 4

ER -

Interferon-γ plays a crucial role in T lymphocyte reaction against alloantigens

Abstract

Keywords

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