INTEGRATED PROFILING OF DIFFUSE LARGE B CELL LYMPHOMA WITH 7q GAIN

E CHIGRINOVA; M MIAN; Y SHEN; GREINER TC; CHAN WC; VOSE JM; G INGHIRAMI; A CHIAPPELLA; L BALDINI; M PONZONI; FERRERI AJM; S FRANCESCHETTI; Gianluca GAIDANO; A TUCCI; F FACCHETTI; T LAZURE; O LAMBOTTE; MORENO S MONTES; PIRIS MA; E ZUCCA; I KWEE; F. BERTONI

doi:10.1111/j.1365-2141.2011.08628.x

INTEGRATED PROFILING OF DIFFUSE LARGE B CELL LYMPHOMA WITH 7q GAIN

E CHIGRINOVA
, M MIAN
, Y SHEN
, GREINER TC
, CHAN WC
, VOSE JM
, G INGHIRAMI
, A CHIAPPELLA
, L BALDINI
, M PONZONI
, FERRERI AJM
, S FRANCESCHETTI
, Gianluca GAIDANO
, A TUCCI
, F FACCHETTI
, T LAZURE
, O LAMBOTTE
, MORENO S MONTES
, PIRIS MA
, E ZUCCA

I KWEE, F. BERTONI

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60 years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.

Original language	English
Pages (from-to)	499-503
Number of pages	5
Journal	British Journal of Haematology
Volume	153
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.2011.08628.x
Publication status	Published - 2011

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10.1111/j.1365-2141.2011.08628.x

http://hdl.handle.net/11579/12719

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CHIGRINOVA, E., MIAN, M., SHEN, Y., TC, GREINER., WC, CHAN., JM, VOSE., INGHIRAMI, G., CHIAPPELLA, A., BALDINI, L., PONZONI, M., AJM, FERRERI., FRANCESCHETTI, S., GAIDANO, G., TUCCI, A., FACCHETTI, F., LAZURE, T., LAMBOTTE, O., MONTES, MORENO. S., MA, PIRIS., ... BERTONI, F. (2011). INTEGRATED PROFILING OF DIFFUSE LARGE B CELL LYMPHOMA WITH 7q GAIN. British Journal of Haematology, 153(4), 499-503. https://doi.org/10.1111/j.1365-2141.2011.08628.x

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title = "INTEGRATED PROFILING OF DIFFUSE LARGE B CELL LYMPHOMA WITH 7q GAIN",

abstract = "To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60 years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.",

author = "E CHIGRINOVA and M MIAN and Y SHEN and GREINER TC and CHAN WC and VOSE JM and G INGHIRAMI and A CHIAPPELLA and L BALDINI and M PONZONI and FERRERI AJM and S FRANCESCHETTI and Gianluca GAIDANO and A TUCCI and F FACCHETTI and T LAZURE and O LAMBOTTE and MONTES, \{MORENO S\} and PIRIS MA and E ZUCCA and I KWEE and F. BERTONI",

year = "2011",

doi = "10.1111/j.1365-2141.2011.08628.x",

language = "English",

volume = "153",

pages = "499--503",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

CHIGRINOVA, E, MIAN, M, SHEN, Y, TC, GREINER, WC, CHAN, JM, VOSE, INGHIRAMI, G, CHIAPPELLA, A, BALDINI, L, PONZONI, M, AJM, FERRERI, FRANCESCHETTI, S, GAIDANO, G, TUCCI, A, FACCHETTI, F, LAZURE, T, LAMBOTTE, O, MONTES, MORENOS, MA, PIRIS, ZUCCA, E, KWEE, I & BERTONI, F 2011, 'INTEGRATED PROFILING OF DIFFUSE LARGE B CELL LYMPHOMA WITH 7q GAIN', British Journal of Haematology, vol. 153, no. 4, pp. 499-503. https://doi.org/10.1111/j.1365-2141.2011.08628.x

TY - JOUR

T1 - INTEGRATED PROFILING OF DIFFUSE LARGE B CELL LYMPHOMA WITH 7q GAIN

AU - CHIGRINOVA, E

AU - MIAN, M

AU - SHEN, Y

AU - TC, GREINER

AU - WC, CHAN

AU - JM, VOSE

AU - INGHIRAMI, G

AU - CHIAPPELLA, A

AU - BALDINI, L

AU - PONZONI, M

AU - AJM, FERRERI

AU - FRANCESCHETTI, S

AU - GAIDANO, Gianluca

AU - TUCCI, A

AU - FACCHETTI, F

AU - LAZURE, T

AU - LAMBOTTE, O

AU - MONTES, MORENO S

AU - MA, PIRIS

AU - ZUCCA, E

AU - KWEE, I

AU - BERTONI, F.

PY - 2011

Y1 - 2011

N2 - To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60 years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.

AB - To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60 years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.

UR - https://iris.uniupo.it/handle/11579/12719

U2 - 10.1111/j.1365-2141.2011.08628.x

DO - 10.1111/j.1365-2141.2011.08628.x

M3 - Article

SN - 0007-1048

VL - 153

SP - 499

EP - 503

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

INTEGRATED PROFILING OF DIFFUSE LARGE B CELL LYMPHOMA WITH 7q GAIN

Abstract

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