Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.

A. Copani; G. Raciti; V. Bruno; M. A. Sortino; F. Nicoletti; P. L. Canonico; A. Cambria

Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.

A. Copani
, G. Raciti
, V. Bruno
, M. A. Sortino
, F. Nicoletti
, P. L. Canonico
, A. Cambria

Research output: Contribution to journal › Article › peer-review

Abstract

Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.

Original language	English
Pages (from-to)	289-294
Number of pages	6
Journal	Italian Journal of Biochemistry
Volume	40
Issue number	5
Publication status	Published - 1991
Externally published	Yes

Cite this

@article{cfad22f04c064033ad0f940167f55991,

title = "Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.",

abstract = "Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.",

author = "A. Copani and G. Raciti and V. Bruno and Sortino, \{M. A.\} and F. Nicoletti and Canonico, \{P. L.\} and A. Cambria",

year = "1991",

language = "English",

volume = "40",

pages = "289--294",

journal = "Italian Journal of Biochemistry",

issn = "0021-2938",

publisher = "Biomedia srl",

number = "5",

}

TY - JOUR

T1 - Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.

AU - Copani, A.

AU - Raciti, G.

AU - Bruno, V.

AU - Sortino, M. A.

AU - Nicoletti, F.

AU - Canonico, P. L.

AU - Cambria, A.

PY - 1991

Y1 - 1991

N2 - Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.

AB - Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.

UR - https://www.scopus.com/pages/publications/0026212638

M3 - Article

SN - 0021-2938

VL - 40

SP - 289

EP - 294

JO - Italian Journal of Biochemistry

JF - Italian Journal of Biochemistry

IS - 5

ER -

Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.

Abstract

Other files and links

Fingerprint

Cite this