INHIBITORY EFFECT OF THE SOMATOSTATIN ANALOG OCTREOTIDE ON RAT PITUITARY-TUMOR CELL (GH3) PROLIFERATION INVITRO

Giuliana PELICCI; PAGLIACCI MC; L LANFRANCONE; PELICCI PG; F GRIGNANI; I. NICOLETTI

INHIBITORY EFFECT OF THE SOMATOSTATIN ANALOG OCTREOTIDE ON RAT PITUITARY-TUMOR CELL (GH3) PROLIFERATION INVITRO

Giuliana PELICCI
, PAGLIACCI MC
, L LANFRANCONE
, PELICCI PG
, F GRIGNANI
, I. NICOLETTI

Department of Translational Medicine

Research output: Contribution to journal › Article

Abstract

The effects of somatostatin-14 (SS-14) and the somatostatin-analog octreotide (SMS 201-995, Sandostatin) on proliferation of GH₃ pituitary tumor cells were investigated in vitro. SMS 201-995 exerted a significant, but transient, inhibition on GH₃ cell growth which reached a maximum at 24 h and was no longer detectable at 48 h. The concentration that evoked the strongest inhibitory effect was 10 nM SMS 201-995, while lower and higher doses resulted in a less pronounced effect. The inhibitory effect SMS 201-995 exerted on cell proliferation was associated with a dose- and time-related reduction in both c-myc and c-fos mRNA levels. SS-14 had no noteworthy influence on either cell proliferation or c-myc and c-fos protooncogene expression. These data demonstrate that SS-analogs transiently inhibit pituitary tumor cell proliferation in vitro.

Original language	English
Pages (from-to)	657-662
Number of pages	6
Journal	Journal of Endocrinological Investigation
Volume	13
Issue number	8
Publication status	Published - 1990

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SDG 3 Good Health and Well-being

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title = "INHIBITORY EFFECT OF THE SOMATOSTATIN ANALOG OCTREOTIDE ON RAT PITUITARY-TUMOR CELL (GH3) PROLIFERATION INVITRO",

abstract = "The effects of somatostatin-14 (SS-14) and the somatostatin-analog octreotide (SMS 201-995, Sandostatin) on proliferation of GH3 pituitary tumor cells were investigated in vitro. SMS 201-995 exerted a significant, but transient, inhibition on GH3 cell growth which reached a maximum at 24 h and was no longer detectable at 48 h. The concentration that evoked the strongest inhibitory effect was 10 nM SMS 201-995, while lower and higher doses resulted in a less pronounced effect. The inhibitory effect SMS 201-995 exerted on cell proliferation was associated with a dose- and time-related reduction in both c-myc and c-fos mRNA levels. SS-14 had no noteworthy influence on either cell proliferation or c-myc and c-fos protooncogene expression. These data demonstrate that SS-analogs transiently inhibit pituitary tumor cell proliferation in vitro.",

author = "Giuliana PELICCI and PAGLIACCI MC and L LANFRANCONE and PELICCI PG and F GRIGNANI and I. NICOLETTI",

year = "1990",

language = "English",

volume = "13",

pages = "657--662",

journal = "Journal of Endocrinological Investigation",

issn = "0391-4097",

publisher = "Springer Science and Business Media Deutschland GmbH",

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TY - JOUR

T1 - INHIBITORY EFFECT OF THE SOMATOSTATIN ANALOG OCTREOTIDE ON RAT PITUITARY-TUMOR CELL (GH3) PROLIFERATION INVITRO

AU - PELICCI, Giuliana

AU - MC, PAGLIACCI

AU - LANFRANCONE, L

AU - PG, PELICCI

AU - GRIGNANI, F

AU - NICOLETTI, I.

PY - 1990

Y1 - 1990

N2 - The effects of somatostatin-14 (SS-14) and the somatostatin-analog octreotide (SMS 201-995, Sandostatin) on proliferation of GH3 pituitary tumor cells were investigated in vitro. SMS 201-995 exerted a significant, but transient, inhibition on GH3 cell growth which reached a maximum at 24 h and was no longer detectable at 48 h. The concentration that evoked the strongest inhibitory effect was 10 nM SMS 201-995, while lower and higher doses resulted in a less pronounced effect. The inhibitory effect SMS 201-995 exerted on cell proliferation was associated with a dose- and time-related reduction in both c-myc and c-fos mRNA levels. SS-14 had no noteworthy influence on either cell proliferation or c-myc and c-fos protooncogene expression. These data demonstrate that SS-analogs transiently inhibit pituitary tumor cell proliferation in vitro.

AB - The effects of somatostatin-14 (SS-14) and the somatostatin-analog octreotide (SMS 201-995, Sandostatin) on proliferation of GH3 pituitary tumor cells were investigated in vitro. SMS 201-995 exerted a significant, but transient, inhibition on GH3 cell growth which reached a maximum at 24 h and was no longer detectable at 48 h. The concentration that evoked the strongest inhibitory effect was 10 nM SMS 201-995, while lower and higher doses resulted in a less pronounced effect. The inhibitory effect SMS 201-995 exerted on cell proliferation was associated with a dose- and time-related reduction in both c-myc and c-fos mRNA levels. SS-14 had no noteworthy influence on either cell proliferation or c-myc and c-fos protooncogene expression. These data demonstrate that SS-analogs transiently inhibit pituitary tumor cell proliferation in vitro.

UR - https://iris.uniupo.it/handle/11579/33792

M3 - Article

SN - 0391-4097

VL - 13

SP - 657

EP - 662

JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

IS - 8

ER -

INHIBITORY EFFECT OF THE SOMATOSTATIN ANALOG OCTREOTIDE ON RAT PITUITARY-TUMOR CELL (GH3) PROLIFERATION INVITRO

Abstract

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