Induced pluripotent stem cells in hematology: Current and future applications

D. Focosi; G. Amabile; A. Di Ruscio; P. Quaranta; D. G. Tenen; M. Pistello

doi:10.1038/bcj.2014.30

Induced pluripotent stem cells in hematology: Current and future applications

D. Focosi, G. Amabile, A. Di Ruscio, P. Quaranta, D. G. Tenen, M. Pistello

Research output: Contribution to journal › Review article › peer-review

Abstract

Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays approaching effectiveness and clinical grade. Potential uses of this technology include predictive toxicology, drug screening, pathogenetic studies and transplantation. Here, we review the basis of current iPS cell technology and potential applications in hematology, ranging from disease modeling of congenital and acquired hemopathies to hematopoietic stem and other blood cell transplantation.

Original language	English
Article number	211
Journal	Blood Cancer Journal
Volume	4
Issue number	5
DOIs	https://doi.org/10.1038/bcj.2014.30
Publication status	Published - May 2014
Externally published	Yes

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10.1038/bcj.2014.30

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title = "Induced pluripotent stem cells in hematology: Current and future applications",

abstract = "Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays approaching effectiveness and clinical grade. Potential uses of this technology include predictive toxicology, drug screening, pathogenetic studies and transplantation. Here, we review the basis of current iPS cell technology and potential applications in hematology, ranging from disease modeling of congenital and acquired hemopathies to hematopoietic stem and other blood cell transplantation.",

author = "D. Focosi and G. Amabile and {Di Ruscio}, A. and P. Quaranta and Tenen, {D. G.} and M. Pistello",

note = "Funding Information: We are grateful to the Italian Society of Hematology (SIE) and the Italian League against Leukemia (AIL) for supporting funds. GA was supported by the American Italian Cancer Foundation during this work.",

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AU - Quaranta, P.

AU - Tenen, D. G.

AU - Pistello, M.

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AB - Reprogramming somatic cells into induced pluripotent stem (iPS) cells is nowadays approaching effectiveness and clinical grade. Potential uses of this technology include predictive toxicology, drug screening, pathogenetic studies and transplantation. Here, we review the basis of current iPS cell technology and potential applications in hematology, ranging from disease modeling of congenital and acquired hemopathies to hematopoietic stem and other blood cell transplantation.

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Induced pluripotent stem cells in hematology: Current and future applications

Abstract

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