Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis

Mattia BELLAN; Marco QUAGLIA; Alessandra Nerviani; Daniele Mauro; Myles Lewis; Federica Goegan; Antonello Gibbin; Sara Pagani; Livia Salmi; Luca Molinari; Luigi Mario CASTELLO; Gian Carlo Avanzi; Vincenzo CANTALUPPI; Mario PIRISI; Pier Paolo SAINAGHI; Costantino Pitzalis

Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis

Mattia BELLAN
, Marco QUAGLIA
, Alessandra Nerviani
, Daniele Mauro
, Myles Lewis
, Federica Goegan
, Antonello Gibbin
, Sara Pagani
, Livia Salmi
, Luca Molinari
, Luigi Mario CASTELLO
, Gian Carlo Avanzi
, Vincenzo CANTALUPPI
, Mario PIRISI
, Pier Paolo SAINAGHI
, Costantino Pitzalis

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Growth arrest-specific 6 (Gas6) and its receptors have been shown to play a crucial role in the homeostasis of the innate immune system by regulating apoptosis and inflammation. We aimed to verify whether an impairment of this system is associated with systemic lupus erythematosus (SLE) disease activity and with lupus nephritis (LN).

Original language	English
Pages (from-to)	132-138
Number of pages	7
Journal	Clinical and Experimental Rheumatology
Volume	39
Issue number	1
Publication status	Published - 2021

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https://hdl.handle.net/11579/114211

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BELLAN, M., QUAGLIA, M., Nerviani, A., Mauro, D., Lewis, M., Goegan, F., Gibbin, A., Pagani, S., Salmi, L., Molinari, L., CASTELLO, L. M., Avanzi, G. C., CANTALUPPI, V., PIRISI, M., SAINAGHI, P. P., & Pitzalis, C. (2021). Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis. Clinical and Experimental Rheumatology, 39(1), 132-138. https://hdl.handle.net/11579/114211

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title = "Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis",

abstract = "Growth arrest-specific 6 (Gas6) and its receptors have been shown to play a crucial role in the homeostasis of the innate immune system by regulating apoptosis and inflammation. We aimed to verify whether an impairment of this system is associated with systemic lupus erythematosus (SLE) disease activity and with lupus nephritis (LN).",

author = "Mattia BELLAN and Marco QUAGLIA and Alessandra Nerviani and Daniele Mauro and Myles Lewis and Federica Goegan and Antonello Gibbin and Sara Pagani and Livia Salmi and Luca Molinari and CASTELLO, \{Luigi Mario\} and Avanzi, \{Gian Carlo\} and Vincenzo CANTALUPPI and Mario PIRISI and SAINAGHI, \{Pier Paolo\} and Costantino Pitzalis",

note = "Publisher Copyright: {\textcopyright} Copyright CliniCal and Experimental Rheumatology 2021.",

year = "2021",

language = "English",

volume = "39",

pages = "132--138",

journal = "Clinical and Experimental Rheumatology",

issn = "0392-856X",

publisher = "Clinical and Experimental Rheumatology S.A.S.",

number = "1",

}

BELLAN, M , QUAGLIA, M, Nerviani, A, Mauro, D, Lewis, M, Goegan, F, Gibbin, A, Pagani, S, Salmi, L, Molinari, L, CASTELLO, LM, Avanzi, GC, CANTALUPPI, V , PIRISI, M , SAINAGHI, PP & Pitzalis, C 2021, 'Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis', Clinical and Experimental Rheumatology, vol. 39, no. 1, pp. 132-138. <https://hdl.handle.net/11579/114211>

TY - JOUR

T1 - Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis

AU - BELLAN, Mattia

AU - QUAGLIA, Marco

AU - Nerviani, Alessandra

AU - Mauro, Daniele

AU - Lewis, Myles

AU - Goegan, Federica

AU - Gibbin, Antonello

AU - Pagani, Sara

AU - Salmi, Livia

AU - Molinari, Luca

AU - CASTELLO, Luigi Mario

AU - Avanzi, Gian Carlo

AU - CANTALUPPI, Vincenzo

AU - PIRISI, Mario

AU - SAINAGHI, Pier Paolo

AU - Pitzalis, Costantino

PY - 2021

Y1 - 2021

N2 - Growth arrest-specific 6 (Gas6) and its receptors have been shown to play a crucial role in the homeostasis of the innate immune system by regulating apoptosis and inflammation. We aimed to verify whether an impairment of this system is associated with systemic lupus erythematosus (SLE) disease activity and with lupus nephritis (LN).

AB - Growth arrest-specific 6 (Gas6) and its receptors have been shown to play a crucial role in the homeostasis of the innate immune system by regulating apoptosis and inflammation. We aimed to verify whether an impairment of this system is associated with systemic lupus erythematosus (SLE) disease activity and with lupus nephritis (LN).

UR - https://iris.uniupo.it/handle/11579/114211

M3 - Article

SN - 0392-856X

VL - 39

SP - 132

EP - 138

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

IS - 1

ER -

Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis

Abstract

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