In vitro Metabolism of Bumetanide

Giorgio Grosa; Franca Viola; Otto Caputo; Giuseppe Biglino

doi:10.1023/A:1016302203941

In vitro Metabolism of Bumetanide

Giorgio Grosa
, Franca Viola
, Otto Caputo
, Giuseppe Biglino

Research output: Contribution to journal › Article › peer-review

Abstract

A new metabolite of the diuretic drug bumetanide, the 4-[(4′-hydroxy)-phenoxy] analog (7), was identified in incubation mixtures of rat liver microsomes. Phenobarbital and clofibrate pretreatment to induce microsomal enzymes changed the relative amounts of the six metabolites formed. Compound 7was the most prevalent metabolite after clofibrate pretreatment.

Original language	English
Pages (from-to)	274-276
Number of pages	3
Journal	Pharmaceutical Research
Volume	1
Issue number	6
DOIs	https://doi.org/10.1023/A:1016302203941
Publication status	Published - Nov 1984
Externally published	Yes

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title = "In vitro Metabolism of Bumetanide",

abstract = "A new metabolite of the diuretic drug bumetanide, the 4-[(4′-hydroxy)-phenoxy] analog (7), was identified in incubation mixtures of rat liver microsomes. Phenobarbital and clofibrate pretreatment to induce microsomal enzymes changed the relative amounts of the six metabolites formed. Compound 7was the most prevalent metabolite after clofibrate pretreatment.",

author = "Giorgio Grosa and Franca Viola and Otto Caputo and Giuseppe Biglino",

year = "1984",

month = nov,

doi = "10.1023/A:1016302203941",

language = "English",

volume = "1",

pages = "274--276",

journal = "Pharmaceutical Research",

issn = "0724-8741",

publisher = "Springer",

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T1 - In vitro Metabolism of Bumetanide

AU - Grosa, Giorgio

AU - Viola, Franca

AU - Caputo, Otto

AU - Biglino, Giuseppe

PY - 1984/11

Y1 - 1984/11

N2 - A new metabolite of the diuretic drug bumetanide, the 4-[(4′-hydroxy)-phenoxy] analog (7), was identified in incubation mixtures of rat liver microsomes. Phenobarbital and clofibrate pretreatment to induce microsomal enzymes changed the relative amounts of the six metabolites formed. Compound 7was the most prevalent metabolite after clofibrate pretreatment.

AB - A new metabolite of the diuretic drug bumetanide, the 4-[(4′-hydroxy)-phenoxy] analog (7), was identified in incubation mixtures of rat liver microsomes. Phenobarbital and clofibrate pretreatment to induce microsomal enzymes changed the relative amounts of the six metabolites formed. Compound 7was the most prevalent metabolite after clofibrate pretreatment.

UR - https://www.scopus.com/pages/publications/0021711308

U2 - 10.1023/A:1016302203941

DO - 10.1023/A:1016302203941

M3 - Article

SN - 0724-8741

VL - 1

SP - 274

EP - 276

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 6

ER -

In vitro Metabolism of Bumetanide

Abstract

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