In vitro metabolism of azasqualene derivatives and their effects on aminopyrine N-demethylase activity in rat liver microsomes

Keyphrases

• 2,3-Oxidosqualene 33%
• Aminopyrine N-demethylase 100%
• Competitive Inhibition 33%
• Compound I 33%
• Cyclase 33%
• Dimethylamine 66%
• IC50 33%
• In Vitro Metabolism 100%
• Incubation 33%
• Inhibition Activity 33%
• Lipophilicity 33%
• Metabolic Pathway 33%
• Metabolism 66%
• N-oxidation 33%
• N-oxides 66%
• Potent Inhibitor 33%
• Quaternary Ammonium Salt 33%
• Rat Liver Microsomes 100%
• Squalene 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Aminopyrine N Demethylase 100%
• Dimethylamine 100%
• IC50 50%
• Lipophilicity 50%
• Quaternary Ammonium Derivative 50%
• Squalene 100%
• Squalene Derivative 50%