In vitro metabolism of 2-(5-ethylpyridin-2-yl)benzimidazole

O. Caputo; G. Grosa; G. Balliano; F. Rocco; G. Biglino

doi:10.1007/BF03189928

In vitro metabolism of 2-(5-ethylpyridin-2-yl)benzimidazole

O. Caputo
, G. Grosa
, G. Balliano
, F. Rocco
, G. Biglino

Research output: Contribution to journal › Article › peer-review

Abstract

The in vitro metabolic transformation of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied with phenobarbital and 3-methylcholanthrene induced rat liver microsomal fractions containing an NADPH-generating system. The major metabolite was a benzylic oxidation product and a secondary metabolite was also recovered. The metabolites were isolated by TLC and HPLC techniques and identified by comparison with known pure compounds.

Original language	English
Pages (from-to)	47-51
Number of pages	5
Journal	European Journal of Drug Metabolism and Pharmacokinetics
Volume	13
Issue number	1
DOIs	https://doi.org/10.1007/BF03189928
Publication status	Published - Jan 1988
Externally published	Yes

Keywords

2-(5-ethylpyridin-2-yl)benzimidazole
KB-1043
drug metabolism

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10.1007/BF03189928

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abstract = "The in vitro metabolic transformation of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied with phenobarbital and 3-methylcholanthrene induced rat liver microsomal fractions containing an NADPH-generating system. The major metabolite was a benzylic oxidation product and a secondary metabolite was also recovered. The metabolites were isolated by TLC and HPLC techniques and identified by comparison with known pure compounds.",

keywords = "2-(5-ethylpyridin-2-yl)benzimidazole, KB-1043, drug metabolism",

author = "O. Caputo and G. Grosa and G. Balliano and F. Rocco and G. Biglino",

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AU - Caputo, O.

AU - Grosa, G.

AU - Balliano, G.

AU - Rocco, F.

AU - Biglino, G.

PY - 1988/1

Y1 - 1988/1

N2 - The in vitro metabolic transformation of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied with phenobarbital and 3-methylcholanthrene induced rat liver microsomal fractions containing an NADPH-generating system. The major metabolite was a benzylic oxidation product and a secondary metabolite was also recovered. The metabolites were isolated by TLC and HPLC techniques and identified by comparison with known pure compounds.

AB - The in vitro metabolic transformation of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied with phenobarbital and 3-methylcholanthrene induced rat liver microsomal fractions containing an NADPH-generating system. The major metabolite was a benzylic oxidation product and a secondary metabolite was also recovered. The metabolites were isolated by TLC and HPLC techniques and identified by comparison with known pure compounds.

KW - 2-(5-ethylpyridin-2-yl)benzimidazole

KW - KB-1043

KW - drug metabolism

UR - https://www.scopus.com/pages/publications/0023906036

U2 - 10.1007/BF03189928

DO - 10.1007/BF03189928

M3 - Article

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JO - European Journal of Drug Metabolism and Pharmacokinetics

JF - European Journal of Drug Metabolism and Pharmacokinetics

IS - 1

ER -

In vitro metabolism of 2-(5-ethylpyridin-2-yl)benzimidazole

Abstract

Keywords

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