In vitro and in vivo antiserotoninergic effects of 1-isopropylnoradreno-chrome-5-monosemicarbazone (divascan®)

A. Prato; M. Amico-Roxas; P. L. Canonico; F. Drago; G. Clementi

doi:10.1016/S0031-6989(80)80079-8

In vitro and in vivo antiserotoninergic effects of 1-isopropylnoradreno-chrome-5-monosemicarbazone (divascan®)

A. Prato
, M. Amico-Roxas
, P. L. Canonico
, F. Drago
, G. Clementi

Research output: Contribution to journal › Article › peer-review

Abstract

The antiserotoninergic action of Divascan® was tested "in vitro" and "in vivo" The drug was able to counteract serotonin-induced contractions of rat stomach strips, in a reversible and dose-dependent manner, but not histamine or acetylcholine-induced contractions of the guines pig iteum. "In vivo" the drug depressed the diurnal and nocturnal peaks of prolactin (Prl) (4 pm - 12 pm). The "in vitro" and "in vivo" results suggest that Divascan® has a significant antagonistic activity on only serotonin-induced rat stomach contractions and thus an inhibitory action on the central 5-HT neurons by abolishing the circadian ciclicity of Plasma Prl levels.

Original language	English
Pages (from-to)	751-756
Number of pages	6
Journal	Pharmacological Research Communications
Volume	12
Issue number	8
DOIs	https://doi.org/10.1016/S0031-6989(80)80079-8
Publication status	Published - Sept 1980
Externally published	Yes

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10.1016/S0031-6989(80)80079-8

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title = "In vitro and in vivo antiserotoninergic effects of 1-isopropylnoradreno-chrome-5-monosemicarbazone (divascan{\textregistered})",

abstract = "The antiserotoninergic action of Divascan{\textregistered} was tested {"}in vitro{"} and {"}in vivo{"} The drug was able to counteract serotonin-induced contractions of rat stomach strips, in a reversible and dose-dependent manner, but not histamine or acetylcholine-induced contractions of the guines pig iteum. {"}In vivo{"} the drug depressed the diurnal and nocturnal peaks of prolactin (Prl) (4 pm - 12 pm). The {"}in vitro{"} and {"}in vivo{"} results suggest that Divascan{\textregistered} has a significant antagonistic activity on only serotonin-induced rat stomach contractions and thus an inhibitory action on the central 5-HT neurons by abolishing the circadian ciclicity of Plasma Prl levels.",

author = "A. Prato and M. Amico-Roxas and Canonico, \{P. L.\} and F. Drago and G. Clementi",

year = "1980",

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doi = "10.1016/S0031-6989(80)80079-8",

language = "English",

volume = "12",

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journal = "Pharmacological Research Communications",

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TY - JOUR

T1 - In vitro and in vivo antiserotoninergic effects of 1-isopropylnoradreno-chrome-5-monosemicarbazone (divascan®)

AU - Prato, A.

AU - Amico-Roxas, M.

AU - Canonico, P. L.

AU - Drago, F.

AU - Clementi, G.

PY - 1980/9

Y1 - 1980/9

N2 - The antiserotoninergic action of Divascan® was tested "in vitro" and "in vivo" The drug was able to counteract serotonin-induced contractions of rat stomach strips, in a reversible and dose-dependent manner, but not histamine or acetylcholine-induced contractions of the guines pig iteum. "In vivo" the drug depressed the diurnal and nocturnal peaks of prolactin (Prl) (4 pm - 12 pm). The "in vitro" and "in vivo" results suggest that Divascan® has a significant antagonistic activity on only serotonin-induced rat stomach contractions and thus an inhibitory action on the central 5-HT neurons by abolishing the circadian ciclicity of Plasma Prl levels.

AB - The antiserotoninergic action of Divascan® was tested "in vitro" and "in vivo" The drug was able to counteract serotonin-induced contractions of rat stomach strips, in a reversible and dose-dependent manner, but not histamine or acetylcholine-induced contractions of the guines pig iteum. "In vivo" the drug depressed the diurnal and nocturnal peaks of prolactin (Prl) (4 pm - 12 pm). The "in vitro" and "in vivo" results suggest that Divascan® has a significant antagonistic activity on only serotonin-induced rat stomach contractions and thus an inhibitory action on the central 5-HT neurons by abolishing the circadian ciclicity of Plasma Prl levels.

UR - https://www.scopus.com/pages/publications/0019225394

U2 - 10.1016/S0031-6989(80)80079-8

DO - 10.1016/S0031-6989(80)80079-8

M3 - Article

SN - 0031-6989

VL - 12

SP - 751

EP - 756

JO - Pharmacological Research Communications

JF - Pharmacological Research Communications

IS - 8

ER -

In vitro and in vivo antiserotoninergic effects of 1-isopropylnoradreno-chrome-5-monosemicarbazone (divascan®)

Abstract

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